Peptide-mediated DNA condensation for non-viral gene therapy Export

@article{citeulike:5467796, abstract = {The construction of non-viral, virus-like vehicles for gene therapy involves the functionalization of multipartite constructs with nucleic acid-binding, cationic agents. Short basic peptides, alone or as fusion proteins, are appropriate DNA binding and condensing elements, whose incorporation into gene delivery vehicles results in the formation of protein–DNA complexes of appropriate size for cell internalization and intracellular trafficking. We review here the most used cationic peptides for artificial virus construction as well as the recently implemented strategies to control the architecture and biological activities of the resulting nanosized particles.}, author = {Saccardo, Paolo and Villaverde, Antonio and Gonz\'{a}lez-Montalb\'{a}n, Nuria}, citeulike-article-id = {5467796}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.biotechadv.2009.03.004}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0734975009000482}, doi = {10.1016/j.biotechadv.2009.03.004}, issn = {07349750}, journal = {Biotechnology Advances}, keywords = {artificial, binding, cationic, dna, engineering, gene, peptides, protein, therapy, viruses}, month = {July}, number = {4}, pages = {432--438}, posted-at = {2009-10-16 09:08:31}, priority = {4}, title = {Peptide-mediated DNA condensation for non-viral gene therapy}, url = {http://dx.doi.org/10.1016/j.biotechadv.2009.03.004}, volume = {27}, year = {2009} }

TY - JOUR ID - citeulike:5467796 L3 - citeulike-article-id:5467796 N2 - The construction of non-viral, virus-like vehicles for gene therapy involves the functionalization of multipartite constructs with nucleic acid-binding, cationic agents. Short basic peptides, alone or as fusion proteins, are appropriate DNA binding and condensing elements, whose incorporation into gene delivery vehicles results in the formation of protein–DNA complexes of appropriate size for cell internalization and intracellular trafficking. We review here the most used cationic peptides for artificial virus construction as well as the recently implemented strategies to control the architecture and biological activities of the resulting nanosized particles. IS - 4 JF - Biotechnology Advances SN - 07349750 EP - 438 TI - Peptide-mediated DNA condensation for non-viral gene therapy VL - 27 SP - 432 KW - artificial KW - binding KW - cationic KW - dna KW - engineering KW - gene KW - peptides KW - protein KW - therapy KW - viruses AU - Saccardo, Paolo AU - Villaverde, Antonio AU - González-Montalbán, Nuria PY - 2009/07// UR - http://dx.doi.org/10.1016/j.biotechadv.2009.03.004 ER -