Mapping the functional connectivity of anterior cingulate cortex. Export

@article{citeulike:1730078, abstract = {Anterior cingulate cortex (ACC) is a nexus of information processing and regulation in the brain. Reflecting this central role, ACC is structurally and functionally heterogeneous, a fact long appreciated in studies of non-human primates. Human neuroimaging studies also recognize this functional heterogeneity, with meta-analyses and task-based studies demonstrating the existence of motor, cognitive and affective subdivisions. In contrast to task-based approaches, examinations of resting-state functional connectivity enable the characterization of task-independent patterns of correlated activity. In a novel approach to understanding ACC functional segregation, we systematically mapped ACC functional connectivity during rest. We examined patterns of functional connectivity for 16 seed ROIs systematically placed throughout caudal, rostral, and subgenual ACC in each hemisphere. First, our data support the commonly observed rostral/caudal distinction, but also suggest the existence of a dorsal/ventral functional distinction. For each of these distinctions, more fine-grained patterns of differentiation were observed than commonly appreciated in human imaging studies. Second, we demonstrate the presence of negatively predicted relationships between distinct ACC functional networks. In particular, we highlight negative relationships between rostral ACC-based affective networks (including the "default mode network") and dorsal-caudal ACC-based frontoparietal attention networks. Finally, interhemispheric activations were more strongly correlated between homologous regions than in non-homologous regions. We discuss the implications of our work for understanding ACC function and potential applications to clinical populations.}, address = {The Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, 215 Lexington Avenue, 14th Floor, New York, NY 10016, USA.}, author = {Margulies, D. S. and Kelly, A. M. and Uddin, L. Q. and Biswal, B. B. and Castellanos, F. X. and Milham, M. P.}, citeulike-article-id = {1730078}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuroimage.2007.05.019}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1053811907004090}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17604651}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17604651}, citeulike-linkout-4 = {http://www.scopus.com/record/display.url?view=extended&origin=resultslist&eid=2-s2.0-34548851726}, citeulike-linkout-5 = {http://www.sciencedirect.com/science/article/B6WNP-4NT84S7-7/1/abb0a56ad88f692125e768a7489660af}, day = {15}, doi = {10.1016/j.neuroimage.2007.05.019}, issn = {1053-8119}, journal = {Neuroimage}, keywords = {acc, anatomy, connectivity, fmri, humans}, month = {August}, number = {2}, pages = {579--588}, posted-at = {2009-04-22 22:53:36}, priority = {2}, title = {Mapping the functional connectivity of anterior cingulate cortex.}, url = {http://dx.doi.org/10.1016/j.neuroimage.2007.05.019}, volume = {37}, year = {2007} }

TY - JOUR ID - citeulike:1730078 L3 - citeulike-article-id:1730078 N2 - Anterior cingulate cortex (ACC) is a nexus of information processing and regulation in the brain. Reflecting this central role, ACC is structurally and functionally heterogeneous, a fact long appreciated in studies of non-human primates. Human neuroimaging studies also recognize this functional heterogeneity, with meta-analyses and task-based studies demonstrating the existence of motor, cognitive and affective subdivisions. In contrast to task-based approaches, examinations of resting-state functional connectivity enable the characterization of task-independent patterns of correlated activity. In a novel approach to understanding ACC functional segregation, we systematically mapped ACC functional connectivity during rest. We examined patterns of functional connectivity for 16 seed ROIs systematically placed throughout caudal, rostral, and subgenual ACC in each hemisphere. First, our data support the commonly observed rostral/caudal distinction, but also suggest the existence of a dorsal/ventral functional distinction. For each of these distinctions, more fine-grained patterns of differentiation were observed than commonly appreciated in human imaging studies. Second, we demonstrate the presence of negatively predicted relationships between distinct ACC functional networks. In particular, we highlight negative relationships between rostral ACC-based affective networks (including the "default mode network") and dorsal-caudal ACC-based frontoparietal attention networks. Finally, interhemispheric activations were more strongly correlated between homologous regions than in non-homologous regions. We discuss the implications of our work for understanding ACC function and potential applications to clinical populations. IS - 2 JF - Neuroimage SN - 1053-8119 AD - The Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, 215 Lexington Avenue, 14th Floor, New York, NY 10016, USA. EP - 588 TI - Mapping the functional connectivity of anterior cingulate cortex. VL - 37 SP - 579 KW - acc KW - anatomy KW - connectivity KW - fmri KW - humans AU - Margulies, DS AU - Kelly, AM AU - Uddin, LQ AU - Biswal, BB AU - Castellanos, FX AU - Milham, MP PY - 2007/08/15/ UR - http://dx.doi.org/10.1016/j.neuroimage.2007.05.019 ER -