Mnemonic Function of Lateral Prefrontal Cortex in Conflict-Induced Behavioral Adjustment Export

@article{citeulike:1826158, abstract = {Our cognitive abilities in performing tasks are influenced by experienced competition/conflict between behavioral choices. To determine the role of anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) in conflict detection/resolution process, we conducted complementary lesion and single-cell recording studies in monkeys resolving a conflict between two rules. We observed conflict-induced behavioral adjustment that persisted after lesions within ACC, but disappeared following lesions within DLPFC. Activity in some cells within DLPFC was modulated by the current conflict level and in other cells by the conflict experienced in previous trial. These results show that DLPFC, but not ACC, is essential for the conflict-induced behavioral adjustment and suggest that encoding and maintenance of information about experienced conflict is mediated by DLPFC. 10.1126/science.1146384}, author = {Mansouri, Farshad A. and Buckley, Mark J. and Tanaka, Keiji}, citeulike-article-id = {1826158}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1146384}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/318/5852/987}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17962523}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17962523}, day = {25}, doi = {10.1126/science.1146384}, journal = {Science}, keywords = {acc, conflict, dlpfc, lesion, pfc, wcst}, month = {October}, pages = {1146384+}, posted-at = {2009-04-23 16:58:05}, priority = {2}, title = {Mnemonic Function of Lateral Prefrontal Cortex in Conflict-Induced Behavioral Adjustment}, url = {http://dx.doi.org/10.1126/science.1146384}, year = {2007} }

TY - JOUR ID - citeulike:1826158 L3 - citeulike-article-id:1826158 N2 - Our cognitive abilities in performing tasks are influenced by experienced competition/conflict between behavioral choices. To determine the role of anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) in conflict detection/resolution process, we conducted complementary lesion and single-cell recording studies in monkeys resolving a conflict between two rules. We observed conflict-induced behavioral adjustment that persisted after lesions within ACC, but disappeared following lesions within DLPFC. Activity in some cells within DLPFC was modulated by the current conflict level and in other cells by the conflict experienced in previous trial. These results show that DLPFC, but not ACC, is essential for the conflict-induced behavioral adjustment and suggest that encoding and maintenance of information about experienced conflict is mediated by DLPFC. 10.1126/science.1146384 JF - Science TI - Mnemonic Function of Lateral Prefrontal Cortex in Conflict-Induced Behavioral Adjustment SP - 1146384 KW - acc KW - conflict KW - dlpfc KW - lesion KW - pfc KW - wcst AU - Mansouri, Farshad AU - Buckley, Mark AU - Tanaka, Keiji PY - 2007/10/25/ UR - http://dx.doi.org/10.1126/science.1146384 ER -