Update on stress and depression: the role of the hypothalamic-pituitary-adrenal (HPA) axis. Export

@article{citeulike:6053538, abstract = {Over the past 50 years, relationships between stress and the neurobiological changes seen in psychiatric disorders have been well-documented. A major focus of investigations in this area has been the role of the hypothalamic-pituitary-adrenal (HPA) axis, both as a marker of stress response and as a mediator of additional downstream pathophysiologic changes. This review examines the emerging literature concerning the relationship between stress, HPA axis function, and depression, as well as the role of early life stress as an important risk factor for HPA axis dysregulation. The more recent studies reviewed suggest that the prominence of HPA axis hyperactivity in adults with depressive and anxiety disorders may constitute a link between the occurrence of adversity in childhood and the development of adult psychopathology.}, author = {Mello, Andrea de Abreu Feij\'{o} de A. and Mello, Marcelo Feij\'{o} de F. and Carpenter, Linda L. and Price, Lawrence H.}, citeulike-article-id = {6053538}, citeulike-linkout-0 = {http://dx.doi.org//S1516-44462003000400010}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15328550}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15328550}, doi = {/S1516-44462003000400010}, issn = {1516-4446}, journal = {Revista brasileira de psiquiatria (S\~{a}o Paulo, Brazil : 1999)}, keywords = {abuse, axis, child, childhood, crh, depression, hpa, stress, trauma}, month = {October}, number = {4}, pages = {231--238}, posted-at = {2009-11-01 13:58:34}, priority = {2}, title = {Update on stress and depression: the role of the hypothalamic-pituitary-adrenal (HPA) axis.}, url = {http://dx.doi.org//S1516-44462003000400010}, volume = {25}, year = {2003} }

TY - JOUR ID - citeulike:6053538 L3 - citeulike-article-id:6053538 N2 - Over the past 50 years, relationships between stress and the neurobiological changes seen in psychiatric disorders have been well-documented. A major focus of investigations in this area has been the role of the hypothalamic-pituitary-adrenal (HPA) axis, both as a marker of stress response and as a mediator of additional downstream pathophysiologic changes. This review examines the emerging literature concerning the relationship between stress, HPA axis function, and depression, as well as the role of early life stress as an important risk factor for HPA axis dysregulation. The more recent studies reviewed suggest that the prominence of HPA axis hyperactivity in adults with depressive and anxiety disorders may constitute a link between the occurrence of adversity in childhood and the development of adult psychopathology. IS - 4 JF - Revista brasileira de psiquiatria (São Paulo, Brazil : 1999) SN - 1516-4446 EP - 238 TI - Update on stress and depression: the role of the hypothalamic-pituitary-adrenal (HPA) axis. VL - 25 SP - 231 KW - abuse KW - axis KW - child KW - childhood KW - crh KW - depression KW - hpa KW - stress KW - trauma AU - Mello, Andrea de Abreu Feijó de AU - Mello, Marcelo Feijó de AU - Carpenter, Linda AU - Price, Lawrence PY - 2003/10// UR - http://dx.doi.org//S1516-44462003000400010 ER -