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Hierarchical and metabolic regulation of glucose influx in starved Saccharomyces cerevisiae Export

FEMS Yeast Research, Vol. 5, No. 6-7. (2005), pp. 611-619.

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glucose hierarchical influx metabolic regulation saccharomyces

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Abstract A novel method dissecting the regulation of a cellular function into direct metabolic regulation and hierarchical (e.g., gene-expression) regulation is applied to yeast starved for nitrogen or carbon. Upon nitrogen starvation glucose influx is down-regulated hierarchically. Upon carbon starvation it is down-regulated both metabolically and hierarchically. The method is expounded in terms of its implications for diverse types of regulation. It is also fine-tuned for cases where isoenzymes catalyze the flux through a single metabolic step.


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