RNA antitoxins Export

@article{citeulike:2387637, abstract = {Recent genomic analyses revealed a surprisingly large number of toxin-antitoxin loci in free-living prokaryotes. The antitoxins are proteins or antisense RNAs that counteract the toxins. Two antisense RNA-regulated toxin-antitoxin gene families, hok/sok and ldr, are unrelated sequence-wise but have strikingly similar properties at the level of gene and RNA organization. Recently, two SOS-induced toxins were found to be regulated by RNA antitoxins. One such toxin, SymE, exhibits similarity with MazE antitoxin and, surprisingly, inhibits translation. Thus, it is possible that an ancestral antitoxin gene evolved into the present toxin gene (symE) whose translation is repressed by an RNA antitoxin (SymR).}, author = {Gerdes, Kenn and Wagner}, booktitle = {Cell regulation (RNA special issue)}, citeulike-article-id = {2387637}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.mib.2007.03.003}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17376733}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17376733}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6VS2-4NC5VBB-2/2/783c7ad34b29b1f10d9dc1270318aaec}, doi = {10.1016/j.mib.2007.03.003}, journal = {Current Opinion in Microbiology}, keywords = {antisense, hok, review, rna, rnaseiii, sok}, month = {April}, number = {2}, pages = {117--124}, posted-at = {2008-02-16 00:12:33}, priority = {0}, title = {RNA antitoxins}, url = {http://dx.doi.org/10.1016/j.mib.2007.03.003}, volume = {10}, year = {2007} }

TY - JOUR ID - citeulike:2387637 L3 - citeulike-article-id:2387637 N2 - Recent genomic analyses revealed a surprisingly large number of toxin-antitoxin loci in free-living prokaryotes. The antitoxins are proteins or antisense RNAs that counteract the toxins. Two antisense RNA-regulated toxin-antitoxin gene families, hok/sok and ldr, are unrelated sequence-wise but have strikingly similar properties at the level of gene and RNA organization. Recently, two SOS-induced toxins were found to be regulated by RNA antitoxins. One such toxin, SymE, exhibits similarity with MazE antitoxin and, surprisingly, inhibits translation. Thus, it is possible that an ancestral antitoxin gene evolved into the present toxin gene (symE) whose translation is repressed by an RNA antitoxin (SymR). IS - 2 JF - Current Opinion in Microbiology EP - 124 TI - RNA antitoxins VL - 10 T2 - Cell regulation (RNA special issue) SP - 117 KW - antisense KW - hok KW - review KW - rna KW - rnaseiii KW - sok AU - Gerdes, Kenn AU - Wagner PY - 2007/04// UR - http://dx.doi.org/10.1016/j.mib.2007.03.003 ER -