DNA signatures for detecting genetic engineering in bacteria Export

@article{citeulike:2563139, abstract = {Using newly designed computational tools we show that, despite substantial shared sequences between natural plasmids and artificial vector sequences, a robust set of DNA oligomers can be identified that can differentiate artificial vector sequences from all available background viral and bacterial genomes and natural plasmids. We predict that these tools can achieve very high sensitivity and specificity rates for detecting new unsequenced vectors in microarray-based bioassays. Such DNA signatures could be important in detecting genetically engineered bacteria in environmental samples.}, author = {Allen, Jonathan and Gardner, Shea and Slezak, Tom}, citeulike-article-id = {2563139}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/gb-2008-9-3-r56}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18348716}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18348716}, day = {18}, doi = {10.1186/gb-2008-9-3-r56}, issn = {1465-6906}, journal = {Genome Biology}, keywords = {detection}, month = {March}, number = {3}, pages = {R56+}, posted-at = {2008-06-15 22:12:56}, priority = {0}, title = {DNA signatures for detecting genetic engineering in bacteria}, url = {http://dx.doi.org/10.1186/gb-2008-9-3-r56}, volume = {9}, year = {2008} }

TY - JOUR ID - citeulike:2563139 L3 - citeulike-article-id:2563139 N2 - Using newly designed computational tools we show that, despite substantial shared sequences between natural plasmids and artificial vector sequences, a robust set of DNA oligomers can be identified that can differentiate artificial vector sequences from all available background viral and bacterial genomes and natural plasmids. We predict that these tools can achieve very high sensitivity and specificity rates for detecting new unsequenced vectors in microarray-based bioassays. Such DNA signatures could be important in detecting genetically engineered bacteria in environmental samples. IS - 3 JF - Genome Biology SN - 1465-6906 TI - DNA signatures for detecting genetic engineering in bacteria VL - 9 SP - R56 KW - detection AU - Allen, Jonathan AU - Gardner, Shea AU - Slezak, Tom PY - 2008/03/18/ UR - http://dx.doi.org/10.1186/gb-2008-9-3-r56 ER -