Raised Interleukin-10 is an Indicator of Poor Outcome and Enhanced Systemic Inflammation in Patients with Acute Coronary Syndrome Export

@article{citeulike:1974071, abstract = {Objective: To re-evaluate the relationship between plasma IL-10 concentration at hospital admission and outcome and to investigate the impact of single nucleotide polymorphisms (SNP) in the IL10 gene in patients with non-ST elevation acute coronary syndrome (ACS). Design: Determination of IL-10 plasma concentrations and genotyping of SNPs in the IL10 gene in a prospective trial of patients with ACS and in a group of healthy controls. Patients: 3179 patients in the Fragmin and Fast Revascularisation During Instability in Coronary Artery Disease II trial and 397 healthy controls. Main outcome measures: Mortality and incidence of myocardial infarction at 12 months. Results: The median and interquartile ranges of IL-10 were 0.8 (0.5 - 1.0) pg/ml in healthy controls and 1.1 (0.7 - 1.9) pg/ml in patients (p<0.001). In patients, IL-10 predicted a crude risk increase of death/MI, with the highest risk observed in the fourth quartile (1.7 (1.2 - 2.3) (adjusted odds ratio, 95 \% confidence interval). Adjustment for common risk indicators, including c-reactive protein and interleukin-6, weakened the association to a non-significant level. The 1170 CC genotype weakly predicted increased plasma concentrations of IL-10 in patients (p=0.04) and in controls (p=0.03), which was consistent with the modest association of this allelic variant with coronary disease (p=0.01).Conclusion: In contrast with some previous reports, we conclude that IL-10 reflects a pro-inflammatory state in patients with ACS and therefore suggest that IL-10 is an equally effective biomarker for the risk prediction of future cardiovascular events as other markers of systemic inflammation. 10.1136/hrt.2007.119271}, author = {Malarstig, Anders and Eriksson, Per and Hamsten, Anders and Lindahl, Bertil and Wallentin, Lars and Siegbahn, Agneta}, citeulike-article-id = {1974071}, citeulike-linkout-0 = {http://dx.doi.org/10.1136/hrt.2007.119271}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17690160}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17690160}, day = {9}, doi = {10.1136/hrt.2007.119271}, journal = {Heart}, keywords = {2007, acs, acute-coronary-syndrome, articles, biomarkers, cardiology, chronic-inflammation, coronary-artery-disease, cytokines, il-10, inflammation, inflammatory, inflammatorycytokines, interleukin-10, interleukins, journals, medical, medical-outcomes, medicine, outcomes, peer-reviewed, predictors, research, systemic-inflammation}, month = {August}, pages = {hrt.2007.119271+}, posted-at = {2007-11-24 19:03:41}, priority = {5}, title = {Raised Interleukin-10 is an Indicator of Poor Outcome and Enhanced Systemic Inflammation in Patients with Acute Coronary Syndrome}, url = {http://dx.doi.org/10.1136/hrt.2007.119271}, year = {2007} }

TY - JOUR ID - citeulike:1974071 L3 - citeulike-article-id:1974071 N2 - Objective: To re-evaluate the relationship between plasma IL-10 concentration at hospital admission and outcome and to investigate the impact of single nucleotide polymorphisms (SNP) in the IL10 gene in patients with non-ST elevation acute coronary syndrome (ACS). Design: Determination of IL-10 plasma concentrations and genotyping of SNPs in the IL10 gene in a prospective trial of patients with ACS and in a group of healthy controls. Patients: 3179 patients in the Fragmin and Fast Revascularisation During Instability in Coronary Artery Disease II trial and 397 healthy controls. Main outcome measures: Mortality and incidence of myocardial infarction at 12 months. Results: The median and interquartile ranges of IL-10 were 0.8 (0.5 - 1.0) pg/ml in healthy controls and 1.1 (0.7 - 1.9) pg/ml in patients (p<0.001). In patients, IL-10 predicted a crude risk increase of death/MI, with the highest risk observed in the fourth quartile (1.7 (1.2 - 2.3) (adjusted odds ratio, 95 % confidence interval). Adjustment for common risk indicators, including c-reactive protein and interleukin-6, weakened the association to a non-significant level. The 1170 CC genotype weakly predicted increased plasma concentrations of IL-10 in patients (p=0.04) and in controls (p=0.03), which was consistent with the modest association of this allelic variant with coronary disease (p=0.01).Conclusion: In contrast with some previous reports, we conclude that IL-10 reflects a pro-inflammatory state in patients with ACS and therefore suggest that IL-10 is an equally effective biomarker for the risk prediction of future cardiovascular events as other markers of systemic inflammation. 10.1136/hrt.2007.119271 JF - Heart TI - Raised Interleukin-10 is an Indicator of Poor Outcome and Enhanced Systemic Inflammation in Patients with Acute Coronary Syndrome SP - hrt.2007.119271 KW - 2007 KW - acs KW - acute-coronary-syndrome KW - articles KW - biomarkers KW - cardiology KW - chronic-inflammation KW - coronary-artery-disease KW - cytokines KW - il-10 KW - inflammation KW - inflammatory KW - inflammatorycytokines KW - interleukin-10 KW - interleukins KW - journals KW - medical KW - medical-outcomes KW - medicine KW - outcomes KW - peer-reviewed KW - predictors KW - research KW - systemic-inflammation AU - Malarstig, Anders AU - Eriksson, Per AU - Hamsten, Anders AU - Lindahl, Bertil AU - Wallentin, Lars AU - Siegbahn, Agneta PY - 2007/08/09/ UR - http://dx.doi.org/10.1136/hrt.2007.119271 ER -