Concentrations of interleukins, interferon, and C-reactive protein in stable and unstable angina pectoris. Export

@article{citeulike:1975668, abstract = {We analyzed the concentrations of interleukins (IL)-6, IL-10, IL-12, and IL-18, interferon (IFN)-gamma, and high-sensitivity C-reactive protein (hsCRP) in 40 patients with unstable angina (UAP), 39 patients with stable angina (SAP), and 52 age- and gender-matched controls. Compared with the control group, IL-12 concentrations were significantly higher in both the SAP and UAP groups, especially in the UAP group, and the IL-18 concentrations tended to be higher in the UAP group. Conversely, IL-10 concentrations were significantly lower in the SAP and UAP groups. Both IL-6 and hsCRP concentrations were significantly higher in the UAP group. The levels of hsCRP were positively correlated with inflammatory or proinflammatory cytokines (IL-6, IL-12, and IL-18), and negatively correlated with anti-inflammatory cytokine (IL-10). Moreover, the levels of IL-12 were positively correlated with IL-18, and negatively correlated with IL-10, and the results revealed the T-helper 1 dominant state. These results suggested that the inflammatory response was strongly associated with coronary atherosclerosis and angina pectoris, and that the T-helper 1 dominance may play an important role in these diseases.}, address = {Department of Cardiology, Juntendo University, School of Medicine, Tokyo, Japan.}, author = {Yamashita, H. and Shimada, K. and Seki, E. and Mokuno, H. and Daida, H.}, citeulike-article-id = {1975668}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12521622}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12521622}, day = {15}, issn = {0002-9149}, journal = {Am J Cardiol}, keywords = {abstracts, angina, angina-pectoris, articles, atherosclerosis, c-reactive-protein, cad, cardiology, coronary, coronary-artery-disease, cytokines, inflammation, inflammatory, inflammatory-cytokines, interferon, interleukins, journals, medical, medicine, peer-reviewed, research, stable-angina, th1, th2, unstable-angina}, month = {January}, number = {2}, pages = {133--136}, posted-at = {2007-11-24 22:41:53}, priority = {0}, title = {Concentrations of interleukins, interferon, and C-reactive protein in stable and unstable angina pectoris.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12521622}, volume = {91}, year = {2003} }

TY - JOUR ID - citeulike:1975668 L3 - citeulike-article-id:1975668 N2 - We analyzed the concentrations of interleukins (IL)-6, IL-10, IL-12, and IL-18, interferon (IFN)-gamma, and high-sensitivity C-reactive protein (hsCRP) in 40 patients with unstable angina (UAP), 39 patients with stable angina (SAP), and 52 age- and gender-matched controls. Compared with the control group, IL-12 concentrations were significantly higher in both the SAP and UAP groups, especially in the UAP group, and the IL-18 concentrations tended to be higher in the UAP group. Conversely, IL-10 concentrations were significantly lower in the SAP and UAP groups. Both IL-6 and hsCRP concentrations were significantly higher in the UAP group. The levels of hsCRP were positively correlated with inflammatory or proinflammatory cytokines (IL-6, IL-12, and IL-18), and negatively correlated with anti-inflammatory cytokine (IL-10). Moreover, the levels of IL-12 were positively correlated with IL-18, and negatively correlated with IL-10, and the results revealed the T-helper 1 dominant state. These results suggested that the inflammatory response was strongly associated with coronary atherosclerosis and angina pectoris, and that the T-helper 1 dominance may play an important role in these diseases. IS - 2 JF - Am J Cardiol SN - 0002-9149 AD - Department of Cardiology, Juntendo University, School of Medicine, Tokyo, Japan. EP - 136 TI - Concentrations of interleukins, interferon, and C-reactive protein in stable and unstable angina pectoris. VL - 91 SP - 133 KW - abstracts KW - angina KW - angina-pectoris KW - articles KW - atherosclerosis KW - c-reactive-protein KW - cad KW - cardiology KW - coronary KW - coronary-artery-disease KW - cytokines KW - inflammation KW - inflammatory KW - inflammatory-cytokines KW - interferon KW - interleukins KW - journals KW - medical KW - medicine KW - peer-reviewed KW - research KW - stable-angina KW - th1 KW - th2 KW - unstable-angina AU - Yamashita, H AU - Shimada, K AU - Seki, E AU - Mokuno, H AU - Daida, H PY - 2003/01/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/12521622 ER -