Emergent epileptiform activity in neural networks with weak excitatory synapses. Export

@article{citeulike:4830720, abstract = {Brain electrical activity recorded during an epileptic seizure is frequently associated with rhythmic discharges in cortical networks. Current opinion in clinical neurophysiology is that strongly coupled networks and cellular bursting are prerequisites for the generation of epileptiform activity. Contrary to expectations, we found that weakly coupled cortical networks can create synchronized cellular activity and seizure-like bursting. Evaluation of a range of synaptic parameters in a detailed computational model revealed that seizure-like activity occurs when the excitatory synapses are weakened. Guided by this observation, we confirmed experimentally that, in mouse neocortical slices, a pharmacological reduction of excitatory synaptic transmission elicited sudden onset of repetitive network bursting. Our finding provides powerful evidence that onset of seizures can be associated with a reduction in synaptic transmission. These results open a new avenue to explore network synchrony and may ultimately lead to a rational approach to treatment of network pathology in epilepsy.}, author = {van Drongelen, W. and Lee, H. C. and Hereld, M. and Chen, Z. and Elsen, F. P. and Stevens, R. L.}, citeulike-article-id = {4830720}, citeulike-linkout-0 = {http://dx.doi.org/10.1109/TNSRE.2005.847387}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16003905}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16003905}, doi = {10.1109/TNSRE.2005.847387}, issn = {1534-4320}, journal = {IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society}, keywords = {brain, cortex, epilepsy, excitation, genesis, inhibition, modeling, neural-modeling, neural-networks, seizure}, month = {June}, number = {2}, pages = {236--241}, posted-at = {2009-06-12 22:33:51}, priority = {0}, title = {Emergent epileptiform activity in neural networks with weak excitatory synapses.}, url = {http://dx.doi.org/10.1109/TNSRE.2005.847387}, volume = {13}, year = {2005} }

TY - JOUR ID - citeulike:4830720 L3 - citeulike-article-id:4830720 N2 - Brain electrical activity recorded during an epileptic seizure is frequently associated with rhythmic discharges in cortical networks. Current opinion in clinical neurophysiology is that strongly coupled networks and cellular bursting are prerequisites for the generation of epileptiform activity. Contrary to expectations, we found that weakly coupled cortical networks can create synchronized cellular activity and seizure-like bursting. Evaluation of a range of synaptic parameters in a detailed computational model revealed that seizure-like activity occurs when the excitatory synapses are weakened. Guided by this observation, we confirmed experimentally that, in mouse neocortical slices, a pharmacological reduction of excitatory synaptic transmission elicited sudden onset of repetitive network bursting. Our finding provides powerful evidence that onset of seizures can be associated with a reduction in synaptic transmission. These results open a new avenue to explore network synchrony and may ultimately lead to a rational approach to treatment of network pathology in epilepsy. IS - 2 JF - IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society SN - 1534-4320 EP - 241 TI - Emergent epileptiform activity in neural networks with weak excitatory synapses. VL - 13 SP - 236 KW - brain KW - cortex KW - epilepsy KW - excitation KW - genesis KW - inhibition KW - modeling KW - neural-modeling KW - neural-networks KW - seizure AU - van Drongelen, W AU - Lee, HC AU - Hereld, M AU - Chen, Z AU - Elsen, FP AU - Stevens, RL PY - 2005/06// UR - http://dx.doi.org/10.1109/TNSRE.2005.847387 ER -