Spike timing, calcium signals and synaptic plasticity

by: Per J Sjostrom, Sacha B Nelson

Current Opinion in Neurobiology, Vol. 12, No. 3. (1 June 2002), pp. 305-314.

View FullText article

DOI, ScienceDirect

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

awooga

Find related articles with these CiteULike tags

calcium, model, plasticity, review

Abstract

Plasticity at central synapses depends critically on the timing of presynaptic and postsynaptic action potentials. Key initial steps in synaptic plasticity involve the back-propagation of action potentials into the dendritic tree and calcium influx that depends nonlinearly on the action potential and synaptic input. These initial steps are now better understood. In addition, recent studies of processes as diverse as gene expression and channel inactivation suggest that responses to calcium transients depend not only their amplitude, but on their time course and on the location of their origin.

@article{citeulike:2558159, abstract = {Plasticity at central synapses depends critically on the timing of presynaptic and postsynaptic action potentials. Key initial steps in synaptic plasticity involve the back-propagation of action potentials into the dendritic tree and calcium influx that depends nonlinearly on the action potential and synaptic input. These initial steps are now better understood. In addition, recent studies of processes as diverse as gene expression and channel inactivation suggest that responses to calcium transients depend not only their amplitude, but on their time course and on the location of their origin.}, author = {Sjostrom, Per J. and Nelson, Sacha B. }, citeulike-article-id = {2558159}, doi = {http://dx.doi.org/10.1016/S0959-4388(02)00325-2}, journal = {Current Opinion in Neurobiology}, keywords = {calcium, model, plasticity, review}, month = {June}, number = {3}, pages = {305--314}, posted-at = {2008-03-19 11:19:51}, priority = {0}, title = {Spike timing, calcium signals and synaptic plasticity}, url = {http://dx.doi.org/10.1016/S0959-4388(02)00325-2}, volume = {12}, year = {2002} }

RIS record

TY - JOUR ID - citeulike:2558159 L3 - citeulike-article-id:2558159 TI - Spike timing, calcium signals and synaptic plasticity JF - Current Opinion in Neurobiology VL - 12 IS - 3 SP - 305 EP - 314 N2 - Plasticity at central synapses depends critically on the timing of presynaptic and postsynaptic action potentials. Key initial steps in synaptic plasticity involve the back-propagation of action potentials into the dendritic tree and calcium influx that depends nonlinearly on the action potential and synaptic input. These initial steps are now better understood. In addition, recent studies of processes as diverse as gene expression and channel inactivation suggest that responses to calcium transients depend not only their amplitude, but on their time course and on the location of their origin. KW - calcium KW - model KW - plasticity KW - review AU - Sjostrom, Per AU - Nelson, Sacha PY - 2002/06/01/ UR - http://dx.doi.org/10.1016/S0959-4388(02)00325-2 ER -

RIS BibTeX