A unified model of NMDA receptor-dependent bidirectional synaptic plasticity.

@article{citeulike:2567765, abstract = {Synapses in the brain are bidirectionally modifiable, but the routes of induction are diverse. In various experimental paradigms, N-methyl-d-aspartate receptor-dependent long-term depression and long-term potentiation have been induced selectively by varying the membrane potential of the postsynaptic neurons during presynaptic stimulation of a constant frequency, the rate of presynaptic stimulation, and the timing of pre- and postsynaptic action potentials. In this paper, we present a mathematical embodiment of bidirectional synaptic plasticity that is able to explain diverse induction protocols with a fixed set of parameters. The key assumptions and consequences of the model can be tested experimentally; further, the model provides the foundation for a unified theory of N-methyl-d-aspartate receptor-dependent synaptic plasticity.}, address = {Institute for Brain and Neural Systems, Brown University, Providence, RI 02912, USA. hzs@cns.brown.edu}, author = {Shouval, H. Z. and Bear, M. F. and Cooper, L. N. }, citeulike-article-id = {2567765}, doi = {10.1073/pnas.152343099}, issn = {0027-8424}, journal = {Proc Natl Acad Sci U S A}, month = {August}, number = {16}, pages = {10831--10836}, posted-at = {2008-03-20 17:52:05}, priority = {0}, title = {A unified model of NMDA receptor-dependent bidirectional synaptic plasticity.}, url = {http://dx.doi.org/10.1073/pnas.152343099}, volume = {99}, year = {2002} }

TY - JOUR ID - citeulike:2567765 L3 - citeulike-article-id:2567765 TI - A unified model of NMDA receptor-dependent bidirectional synaptic plasticity. JF - Proc Natl Acad Sci U S A VL - 99 IS - 16 SP - 10831 EP - 10836 AD - Institute for Brain and Neural Systems, Brown University, Providence, RI 02912, USA. hzs@cns.brown.edu SN - 0027-8424 N2 - Synapses in the brain are bidirectionally modifiable, but the routes of induction are diverse. In various experimental paradigms, N-methyl-d-aspartate receptor-dependent long-term depression and long-term potentiation have been induced selectively by varying the membrane potential of the postsynaptic neurons during presynaptic stimulation of a constant frequency, the rate of presynaptic stimulation, and the timing of pre- and postsynaptic action potentials. In this paper, we present a mathematical embodiment of bidirectional synaptic plasticity that is able to explain diverse induction protocols with a fixed set of parameters. The key assumptions and consequences of the model can be tested experimentally; further, the model provides the foundation for a unified theory of N-methyl-d-aspartate receptor-dependent synaptic plasticity. AU - Shouval, HZ AU - Bear, MF AU - Cooper, LN PY - 2002/08/06/ UR - http://dx.doi.org/10.1073/pnas.152343099 ER -