Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia.

@article{citeulike:2393452, abstract = {Respiratory infections with Pseudomonas aeruginosa and Burkholderia cepacia play a major role in the pathogenesis of cystic fibrosis (CF). This review summarizes the latest advances in understanding host-pathogen interactions in CF with an emphasis on the role and control of conversion to mucoidy in P. aeruginosa, a phenomenon epitomizing the adaptation of this opportunistic pathogen to the chronic chourse of infection in CF, and on the innate resistance to antibiotics of B. cepacia, person-to-person spread, and sometimes rapidly fatal disease caused by this organism. While understanding the mechanism of conversion to mucoidy in P. aeruginosa has progressed to the point where this phenomenon has evolved into a model system for studying bacterial stress response in microbial pathogenesis, the more recent challenge with B. cepacia, which has emerged as a potent bona fide CF pathogen, is discussed in the context of clinical issues, taxonomy, transmission, and potential modes of pathogenicity.}, address = {Department of Medical Microbiology, University of Edinburgh Medical School, Scotland.}, author = {Govan, J. R. and Deretic, V. }, citeulike-article-id = {2393452}, issn = {0146-0749}, journal = {Microbiol Rev}, keywords = {aeruginosa, burkholderia, cf}, month = {September}, number = {3}, pages = {539--574}, posted-at = {2008-02-18 11:15:12}, priority = {2}, title = {Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8840786}, volume = {60}, year = {1996} }

TY - JOUR ID - citeulike:2393452 L3 - citeulike-article-id:2393452 TI - Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. JF - Microbiol Rev VL - 60 IS - 3 SP - 539 EP - 574 AD - Department of Medical Microbiology, University of Edinburgh Medical School, Scotland. SN - 0146-0749 N2 - Respiratory infections with Pseudomonas aeruginosa and Burkholderia cepacia play a major role in the pathogenesis of cystic fibrosis (CF). This review summarizes the latest advances in understanding host-pathogen interactions in CF with an emphasis on the role and control of conversion to mucoidy in P. aeruginosa, a phenomenon epitomizing the adaptation of this opportunistic pathogen to the chronic chourse of infection in CF, and on the innate resistance to antibiotics of B. cepacia, person-to-person spread, and sometimes rapidly fatal disease caused by this organism. While understanding the mechanism of conversion to mucoidy in P. aeruginosa has progressed to the point where this phenomenon has evolved into a model system for studying bacterial stress response in microbial pathogenesis, the more recent challenge with B. cepacia, which has emerged as a potent bona fide CF pathogen, is discussed in the context of clinical issues, taxonomy, transmission, and potential modes of pathogenicity. KW - aeruginosa KW - burkholderia KW - cf AU - Govan, JR AU - Deretic, V PY - 1996/09// UR - http://view.ncbi.nlm.nih.gov/pubmed/8840786 ER -