Type V Protein Secretion Pathway: the Autotransporter Story Export

@article{citeulike:1020923, abstract = {Gram-negative bacteria possess an outer membrane layer which constrains uptake and secretion of solutes and polypeptides. To overcome this barrier, bacteria have developed several systems for protein secretion. The type V secretion pathway encompasses the autotransporter proteins, the two-partner secretion system, and the recently described type Vc or AT-2 family of proteins. Since its discovery in the late 1980s, this family of secreted proteins has expanded continuously, due largely to the advent of the genomic age, to become the largest group of secreted proteins in gram-negative bacteria. Several of these proteins play essential roles in the pathogenesis of bacterial infections and have been characterized in detail, demonstrating a diverse array of function including the ability to condense host cell actin and to modulate apoptosis. However, most of the autotransporter proteins remain to be characterized. In light of new discoveries and controversies in this research field, this review considers the autotransporter secretion process in the context of the more general field of bacterial protein translocation and exoprotein function. 10.1128/MMBR.68.4.692-744.2004}, author = {Henderson, Ian R. and Navarro-Garcia, Fernando and Desvaux, Mickael and Fernandez, Rachel C. and Ala'aldeen, Dlawer}, citeulike-article-id = {1020923}, citeulike-linkout-0 = {http://dx.doi.org/10.1128/MMBR.68.4.692}, citeulike-linkout-1 = {http://mmbr.asm.org/cgi/content/abstract/68/4/692}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15590781}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15590781}, day = {1}, doi = {10.1128/MMBR.68.4.692}, journal = {Microbiol. Mol. Biol. Rev.}, keywords = {bactjav}, month = {December}, number = {4}, pages = {692--744}, posted-at = {2006-12-31 16:30:27}, priority = {5}, title = {Type V Protein Secretion Pathway: the Autotransporter Story}, url = {http://dx.doi.org/10.1128/MMBR.68.4.692}, volume = {68}, year = {2004} }

TY - JOUR ID - citeulike:1020923 L3 - citeulike-article-id:1020923 N2 - Gram-negative bacteria possess an outer membrane layer which constrains uptake and secretion of solutes and polypeptides. To overcome this barrier, bacteria have developed several systems for protein secretion. The type V secretion pathway encompasses the autotransporter proteins, the two-partner secretion system, and the recently described type Vc or AT-2 family of proteins. Since its discovery in the late 1980s, this family of secreted proteins has expanded continuously, due largely to the advent of the genomic age, to become the largest group of secreted proteins in gram-negative bacteria. Several of these proteins play essential roles in the pathogenesis of bacterial infections and have been characterized in detail, demonstrating a diverse array of function including the ability to condense host cell actin and to modulate apoptosis. However, most of the autotransporter proteins remain to be characterized. In light of new discoveries and controversies in this research field, this review considers the autotransporter secretion process in the context of the more general field of bacterial protein translocation and exoprotein function. 10.1128/MMBR.68.4.692-744.2004 IS - 4 JF - Microbiol. Mol. Biol. Rev. EP - 744 TI - Type V Protein Secretion Pathway: the Autotransporter Story VL - 68 SP - 692 KW - bactjav AU - Henderson, Ian AU - Navarro-Garcia, Fernando AU - Desvaux, Mickael AU - Fernandez, Rachel AU - Ala'aldeen, Dlawer PY - 2004/12/01/ UR - http://dx.doi.org/10.1128/MMBR.68.4.692 ER -