A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate Export

@article{citeulike:230862, abstract = {Under prevailing theories, the nonsynonymous-to-synonymous substitution ratio (i.e. Ka/Ks), which measures the fixation probability of nonsynonymous mutations, is correlated with the strength of selection. In this article, we report that Ka/Ks is also strongly correlated with the mutation rate as measured by Ks, and that this correlation appears to have a similar magnitude as the correlation between Ka/Ks and selective strength. This finding cannot be reconciled with current theories. It suggests that we should re-evaluate the current paradigms of coding-sequence evolution, and that the wide use of Ka/Ks as a measure of selective strength needs reassessment.}, author = {Wyckoff, Gerald J. and Malcom, Christine M. and Vallender, Eric J. and Lahn, Bruce T.}, citeulike-article-id = {230862}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tig.2005.05.005}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15946765}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15946765}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6TCY-4GBWJ65-1/2/3cfc046d1635bde77c6dc310a1e0d52b}, doi = {10.1016/j.tig.2005.05.005}, journal = {Trends in Genetics}, keywords = {natsel}, posted-at = {2006-05-18 09:52:06}, priority = {2}, title = {A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate}, url = {http://dx.doi.org/10.1016/j.tig.2005.05.005}, volume = {In Press, Corrected Proof} }

TY - JOUR ID - citeulike:230862 L3 - citeulike-article-id:230862 N2 - Under prevailing theories, the nonsynonymous-to-synonymous substitution ratio (i.e. Ka/Ks), which measures the fixation probability of nonsynonymous mutations, is correlated with the strength of selection. In this article, we report that Ka/Ks is also strongly correlated with the mutation rate as measured by Ks, and that this correlation appears to have a similar magnitude as the correlation between Ka/Ks and selective strength. This finding cannot be reconciled with current theories. It suggests that we should re-evaluate the current paradigms of coding-sequence evolution, and that the wide use of Ka/Ks as a measure of selective strength needs reassessment. JF - Trends in Genetics TI - A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate VL - In Press, Corrected Proof KW - natsel AU - Wyckoff, Gerald AU - Malcom, Christine AU - Vallender, Eric AU - Lahn, Bruce UR - http://dx.doi.org/10.1016/j.tig.2005.05.005 ER -