Microcephalin, a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans Export

@article{citeulike:319413, abstract = {The gene Microcephalin (MCPH1) regulates brain size and has evolved under strong positive selection in the human evolutionary lineage. We show that one genetic variant of Microcephalin in modern humans, which arose [\~{}]37,000 years ago, increased in frequency too rapidly to be compatible with neutral drift. This indicates that it has spread under strong positive selection, although the exact nature of the selection is unknown. The finding that an important brain gene has continued to evolve adaptively in anatomically modern humans suggests the ongoing evolutionary plasticity of the human brain. It also makes Microcephalin an attractive candidate locus for studying the genetics of human variation in brain-related phenotypes.}, author = {Evans, Patrick D. and Gilbert, Sandra L. and Mekel-Bobrov, Nitzan and Vallender, Eric J. and Anderson, Jeffrey R. and Vaez-Azizi, Leila M. and Tishkoff, Sarah A. and Hudson, Richard R. and Lahn, Bruce T.}, citeulike-article-id = {319413}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1113722}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/309/5741/1717}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16151009}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16151009}, citeulike-linkout-4 = {http://www.sciencemag.org/cgi/content/full/309/5741/1717}, day = {09}, doi = {10.1126/science.1113722}, journal = {Science}, keywords = {natsel}, month = {September}, number = {5741}, pages = {1717--1720}, posted-at = {2006-05-18 09:51:48}, priority = {2}, title = {Microcephalin, a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans}, url = {http://dx.doi.org/10.1126/science.1113722}, volume = {309}, year = {2005} }

TY - JOUR ID - citeulike:319413 L3 - citeulike-article-id:319413 N2 - The gene Microcephalin (MCPH1) regulates brain size and has evolved under strong positive selection in the human evolutionary lineage. We show that one genetic variant of Microcephalin in modern humans, which arose [~]37,000 years ago, increased in frequency too rapidly to be compatible with neutral drift. This indicates that it has spread under strong positive selection, although the exact nature of the selection is unknown. The finding that an important brain gene has continued to evolve adaptively in anatomically modern humans suggests the ongoing evolutionary plasticity of the human brain. It also makes Microcephalin an attractive candidate locus for studying the genetics of human variation in brain-related phenotypes. IS - 5741 JF - Science EP - 1720 TI - Microcephalin, a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans VL - 309 SP - 1717 KW - natsel AU - Evans, Patrick AU - Gilbert, Sandra AU - Mekel-Bobrov, Nitzan AU - Vallender, Eric AU - Anderson, Jeffrey AU - Vaez-Azizi, Leila AU - Tishkoff, Sarah AU - Hudson, Richard AU - Lahn, Bruce PY - 2005/09/09/ UR - http://dx.doi.org/10.1126/science.1113722 ER -