Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens Export

@article{citeulike:319414, abstract = {The gene ASPM (abnormal spindle-like microcephaly associated) is a specific regulator of brain size, and its evolution in the lineage leading to Homo sapiens was driven by strong positive selection. Here, we show that one genetic variant of ASPM in humans arose merely about 5800 years ago and has since swept to high frequency under strong positive selection. These findings, especially the remarkably young age of the positively selected variant, suggest that the human brain is still undergoing rapid adaptive evolution.}, author = {Mekel-Bobrov, Nitzan and Gilbert, Sandra L. and Evans, Patrick D. and Vallender, Eric J. and Anderson, Jeffrey R. and Hudson, Richard R. and Tishkoff, Sarah A. and Lahn, Bruce T.}, citeulike-article-id = {319414}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1116815}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/309/5741/1720}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16151010}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16151010}, citeulike-linkout-4 = {http://www.sciencemag.org/cgi/content/full/309/5741/1720}, day = {09}, doi = {10.1126/science.1116815}, journal = {Science}, keywords = {natsel}, month = {September}, number = {5741}, pages = {1720--1722}, posted-at = {2006-05-18 09:51:41}, priority = {2}, title = {Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens}, url = {http://dx.doi.org/10.1126/science.1116815}, volume = {309}, year = {2005} }

TY - JOUR ID - citeulike:319414 L3 - citeulike-article-id:319414 N2 - The gene ASPM (abnormal spindle-like microcephaly associated) is a specific regulator of brain size, and its evolution in the lineage leading to Homo sapiens was driven by strong positive selection. Here, we show that one genetic variant of ASPM in humans arose merely about 5800 years ago and has since swept to high frequency under strong positive selection. These findings, especially the remarkably young age of the positively selected variant, suggest that the human brain is still undergoing rapid adaptive evolution. IS - 5741 JF - Science EP - 1722 TI - Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens VL - 309 SP - 1720 KW - natsel AU - Mekel-Bobrov, Nitzan AU - Gilbert, Sandra AU - Evans, Patrick AU - Vallender, Eric AU - Anderson, Jeffrey AU - Hudson, Richard AU - Tishkoff, Sarah AU - Lahn, Bruce PY - 2005/09/09/ UR - http://dx.doi.org/10.1126/science.1116815 ER -