Phenotype ontologies: the bridge between genomics and evolution Export

@article{citeulike:1573529, abstract = {Understanding the developmental and genetic underpinnings of particular evolutionary changes has been hindered by inadequate databases of evolutionary anatomy and by the lack of a computational approach to identify underlying candidate genes and regulators. By contrast, model organism studies have been enhanced by ontologies shared among genomic databases. Here, we suggest that evolutionary and genomics databases can be developed to exchange and use information through shared phenotype and anatomy ontologies. This would facilitate computing on evolutionary questions pertaining to the genetic basis of evolutionary change, the genetic and developmental bases of correlated characters and independent evolution, biomedical parallels to evolutionary change, and the ecological and paleontological correlates of particular types of change in genes, gene networks and developmental pathways.}, author = {Mabee, Paula M. and Ashburner, Michael and Cronk, Quentin and Gkoutos, Georgios V. and Haendel, Melissa and Segerdell, Erik and Mungall, Chris and Westerfield, Monte}, citeulike-article-id = {1573529}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tree.2007.03.013}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6VJ1-4NFR5BM-1/2/e59aad27770b9efa0f088c877c2b4750}, doi = {10.1016/j.tree.2007.03.013}, journal = {Trends in Ecology \& Evolution}, keywords = {comp-ontology, evolution, evolutionary-genomics, genotype-to-phenotype, phenotype-to-genotype, systems-biology}, month = {July}, number = {7}, pages = {345--350}, posted-at = {2008-12-23 17:41:13}, priority = {2}, title = {Phenotype ontologies: the bridge between genomics and evolution}, url = {http://dx.doi.org/10.1016/j.tree.2007.03.013}, volume = {22}, year = {2007} }

TY - JOUR ID - citeulike:1573529 L3 - citeulike-article-id:1573529 N2 - Understanding the developmental and genetic underpinnings of particular evolutionary changes has been hindered by inadequate databases of evolutionary anatomy and by the lack of a computational approach to identify underlying candidate genes and regulators. By contrast, model organism studies have been enhanced by ontologies shared among genomic databases. Here, we suggest that evolutionary and genomics databases can be developed to exchange and use information through shared phenotype and anatomy ontologies. This would facilitate computing on evolutionary questions pertaining to the genetic basis of evolutionary change, the genetic and developmental bases of correlated characters and independent evolution, biomedical parallels to evolutionary change, and the ecological and paleontological correlates of particular types of change in genes, gene networks and developmental pathways. IS - 7 JF - Trends in Ecology & Evolution EP - 350 TI - Phenotype ontologies: the bridge between genomics and evolution VL - 22 SP - 345 KW - comp-ontology KW - evolution KW - evolutionary-genomics KW - genotype-to-phenotype KW - phenotype-to-genotype KW - systems-biology AU - Mabee, Paula AU - Ashburner, Michael AU - Cronk, Quentin AU - Gkoutos, Georgios AU - Haendel, Melissa AU - Segerdell, Erik AU - Mungall, Chris AU - Westerfield, Monte PY - 2007/07// UR - http://dx.doi.org/10.1016/j.tree.2007.03.013 ER -