Evolutionary expansion and anatomical specialization of synapse proteome complexity.

@article{citeulike:2879868, abstract = {Understanding the origins and evolution of synapses may provide insight into species diversity and the organization of the brain. Using comparative proteomics and genomics, we examined the evolution of the postsynaptic density (PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling complexes (MASCs) that underlie learning and memory. PSD and MASC orthologs found in yeast carry out basic cellular functions to regulate protein synthesis and structural plasticity. We observed marked changes in signaling complexity at the yeast-metazoan and invertebrate-vertebrate boundaries, with an expansion of key synaptic components, notably receptors, adhesion/cytoskeletal proteins and scaffold proteins. A proteomic comparison of Drosophila and mouse MASCs revealed species-specific adaptation with greater signaling complexity in mouse. Although synaptic components were conserved amongst diverse vertebrate species, mapping mRNA and protein expression in the mouse brain showed that vertebrate-specific components preferentially contributed to differences between brain regions. We propose that the evolution of synapse complexity around a core proto-synapse has contributed to invertebrate-vertebrate differences and to brain specialization.}, address = {[1] Institute for Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB, UK. [2] These authors contributed equally to this work.}, author = {Emes, Richard D D. and Pocklington, Andrew J J. and Anderson, Christopher N G N. and Bayes, Alex and Collins, Mark O O. and Vickers, Catherine A A. and Croning, Mike D R D. and Malik, Bilal R R. and Choudhary, Jyoti S S. and Armstrong, J Douglas D. and Grant, Seth G N G. }, citeulike-article-id = {2879868}, doi = {http://dx.doi.org/10.1038/nn.2135}, issn = {1097-6256}, journal = {Nature neuroscience}, keywords = {animal-model, brain-anatomy, comparative-neuro, evolution, evolution-of-intelligence, evolutionary-proteomics, evolvability, molecular-signaling, neuro-computation, phylogeny, synaptic-complexity}, month = {June}, posted-at = {2008-06-15 04:50:28}, priority = {4}, title = {Evolutionary expansion and anatomical specialization of synapse proteome complexity.}, url = {http://dx.doi.org/10.1038/nn.2135}, year = {2008} }

TY - JOUR ID - citeulike:2879868 L3 - citeulike-article-id:2879868 TI - Evolutionary expansion and anatomical specialization of synapse proteome complexity. JF - Nature neuroscience AD - [1] Institute for Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB, UK. [2] These authors contributed equally to this work. SN - 1097-6256 N2 - Understanding the origins and evolution of synapses may provide insight into species diversity and the organization of the brain. Using comparative proteomics and genomics, we examined the evolution of the postsynaptic density (PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling complexes (MASCs) that underlie learning and memory. PSD and MASC orthologs found in yeast carry out basic cellular functions to regulate protein synthesis and structural plasticity. We observed marked changes in signaling complexity at the yeast-metazoan and invertebrate-vertebrate boundaries, with an expansion of key synaptic components, notably receptors, adhesion/cytoskeletal proteins and scaffold proteins. A proteomic comparison of Drosophila and mouse MASCs revealed species-specific adaptation with greater signaling complexity in mouse. Although synaptic components were conserved amongst diverse vertebrate species, mapping mRNA and protein expression in the mouse brain showed that vertebrate-specific components preferentially contributed to differences between brain regions. We propose that the evolution of synapse complexity around a core proto-synapse has contributed to invertebrate-vertebrate differences and to brain specialization. KW - animal-model KW - brain-anatomy KW - comparative-neuro KW - evolution KW - evolution-of-intelligence KW - evolutionary-proteomics KW - evolvability KW - molecular-signaling KW - neuro-computation KW - phylogeny KW - synaptic-complexity AU - Emes, Richard D AU - Pocklington, Andrew J AU - Anderson, Christopher N G AU - Bayes, Alex AU - Collins, Mark O AU - Vickers, Catherine A AU - Croning, Mike D R AU - Malik, Bilal R AU - Choudhary, Jyoti S AU - Armstrong, J Douglas AU - Grant, Seth G N PY - 2008/06/08/ UR - http://dx.doi.org/10.1038/nn.2135 ER -