Stochastic coherence in an oscillatory gene circuit model Export

@article{citeulike:2945243, abstract = {We show that noise-induced oscillations in a gene circuit model display stochastic coherence, that is, a maximum in the regularity of the oscillations as a function of noise amplitude. The effect is manifest as a system-size effect in a purely stochastic molecular reaction description of the circuit dynamics. We compare the molecular reaction model behavior with that predicted by a rate equation version of the same system. In addition, we show that commonly used reduced models that ignore fast operator reactions do not capture the full stochastic behavior of the gene circuit. Stochastic coherence occurs under conditions that may be physiologically relevant.}, author = {Hilborn, Robert C. and Erwin, Jessie D.}, citeulike-article-id = {2945243}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jtbi.2008.03.012}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WMD-4S266BS-6/1/781c24d99aa57d4357cf7d4d4cf11437}, day = {21}, doi = {10.1016/j.jtbi.2008.03.012}, journal = {Journal of Theoretical Biology}, keywords = {control-theory, gene-expression, stochastic, switching-examples, time-dynamics, time-oriented-science}, month = {July}, number = {2}, pages = {349--354}, posted-at = {2008-06-30 16:19:35}, priority = {2}, title = {Stochastic coherence in an oscillatory gene circuit model}, url = {http://dx.doi.org/10.1016/j.jtbi.2008.03.012}, volume = {253}, year = {2008} }

TY - JOUR ID - citeulike:2945243 L3 - citeulike-article-id:2945243 N2 - We show that noise-induced oscillations in a gene circuit model display stochastic coherence, that is, a maximum in the regularity of the oscillations as a function of noise amplitude. The effect is manifest as a system-size effect in a purely stochastic molecular reaction description of the circuit dynamics. We compare the molecular reaction model behavior with that predicted by a rate equation version of the same system. In addition, we show that commonly used reduced models that ignore fast operator reactions do not capture the full stochastic behavior of the gene circuit. Stochastic coherence occurs under conditions that may be physiologically relevant. IS - 2 JF - Journal of Theoretical Biology EP - 354 TI - Stochastic coherence in an oscillatory gene circuit model VL - 253 SP - 349 KW - control-theory KW - gene-expression KW - stochastic KW - switching-examples KW - time-dynamics KW - time-oriented-science AU - Hilborn, Robert AU - Erwin, Jessie PY - 2008/07/21/ UR - http://dx.doi.org/10.1016/j.jtbi.2008.03.012 ER -