The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs. Export

@article{citeulike:3774091, abstract = {In model organisms, chemical mutagenesis provides a powerful alternative to natural, polygenic variation (for example, quantitative trait loci (QTLs)) for identifying functional pathways and complex disease genes. Despite recent progress in QTLs, we expect that mutagenesis will ultimately prove more effective because the prospects of gene identification are high and every gene affecting a trait is potentially a target.}, author = {Nadeau, J. H. and Frankel, W. N.}, citeulike-article-id = {3774091}, journal = {Nature Genetics}, keywords = {anthropometry, genome-association, genome-prediction, genotype-to-phenotype, phenotype-to-genotype, reviews}, pages = {381--384}, posted-at = {2008-12-11 17:30:23}, priority = {2}, title = {The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs.}, volume = {25}, year = {2000} }

TY - JOUR ID - citeulike:3774091 L3 - citeulike-article-id:3774091 N2 - In model organisms, chemical mutagenesis provides a powerful alternative to natural, polygenic variation (for example, quantitative trait loci (QTLs)) for identifying functional pathways and complex disease genes. Despite recent progress in QTLs, we expect that mutagenesis will ultimately prove more effective because the prospects of gene identification are high and every gene affecting a trait is potentially a target. JF - Nature Genetics EP - 384 TI - The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs. VL - 25 SP - 381 KW - anthropometry KW - genome-association KW - genome-prediction KW - genotype-to-phenotype KW - phenotype-to-genotype KW - reviews AU - Nadeau, JH AU - Frankel, WN PY - 2000/// ER -