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Long-term potentiation induced by physiologically relevant stimulus patterns. Export

Brain research, Vol. 435, No. 1-2. (1 December 1987), pp. 331-333.

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adaptive-systems brain-anatomy in-vitro learning-and-memory methods reviews

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Single pulse stimuli were delivered to the Schaffer collaterals in the in vitro hippocampal slice preparation. Local application of bicuculline to the CA3 region resulted in a series of population cell bursts in CA3, resembling the neuronal patterns which occur in the normal, freely moving rat during hippocampal sharp waves. These bicuculline-induced cell bursts in CA3 resulted in long-term potentiation (LTP) of the CA1 response. These findings suggest that the naturally occurring hippocampal sharp waves may reflect events analogous to artificially induced LTP.


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