Physiological gain leads to high ISI variability in a simple model of a cortical regular spiking cell. Export

@article{citeulike:802309, abstract = {To understand the interspike interval (ISI) variability displayed by visual cortical neurons (Softky \& Koch, 1993), it is critical to examine the dynamics of their neuronal integration, as well as the variability in their synaptic input current. Most previous models have focused on the latter factor. We match a simple integrate-and-fire model to the experimentally measured integrative properties of cortical regular spiking cells (McCormick, Connors, Lighthall, \& Prince, 1985). After setting RC parameters, the post-spike voltage reset is set to match experimental measurements of neuronal gain (obtained from in vitro plots of firing frequency versus injected current). Examination of the resulting model leads to an intuitive picture of neuronal integration that unifies the seemingly contradictory 1/square root of N and random walk pictures that have previously been proposed. When ISIs are dominated by postspike recovery, 1/square root of N arguments hold and spiking is regular; after the "memory" of the last spike becomes negligible, spike threshold crossing is caused by input variance around a steady state and spiking is Poisson. In integrate-and-fire neurons matched to cortical cell physiology, steady-state behavior is predominant, and ISIs are highly variable at all physiological firing rates and for a wide range of inhibitory and excitatory inputs.}, address = {Keck Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco 94143, USA.}, author = {Troyer, T. W. and Miller, K. D.}, citeulike-article-id = {802309}, citeulike-linkout-0 = {http://neco.mitpress.org/cgi/content/abstract/9/5/971}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/9188190}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=9188190}, day = {1}, issn = {0899-7667}, journal = {Neural Comput}, keywords = {cell-models, control-theory, neuro-coding, neuro-computation, neuro-spike, neuro-sync, neuro-timing, neuroplasticity, time-course, time-dynamics}, month = {July}, number = {5}, pages = {971--983}, posted-at = {2008-06-29 21:36:10}, priority = {2}, title = {Physiological gain leads to high ISI variability in a simple model of a cortical regular spiking cell.}, url = {http://neco.mitpress.org/cgi/content/abstract/9/5/971}, volume = {9}, year = {1997} }

TY - JOUR ID - citeulike:802309 L3 - citeulike-article-id:802309 N2 - To understand the interspike interval (ISI) variability displayed by visual cortical neurons (Softky & Koch, 1993), it is critical to examine the dynamics of their neuronal integration, as well as the variability in their synaptic input current. Most previous models have focused on the latter factor. We match a simple integrate-and-fire model to the experimentally measured integrative properties of cortical regular spiking cells (McCormick, Connors, Lighthall, & Prince, 1985). After setting RC parameters, the post-spike voltage reset is set to match experimental measurements of neuronal gain (obtained from in vitro plots of firing frequency versus injected current). Examination of the resulting model leads to an intuitive picture of neuronal integration that unifies the seemingly contradictory 1/square root of N and random walk pictures that have previously been proposed. When ISIs are dominated by postspike recovery, 1/square root of N arguments hold and spiking is regular; after the "memory" of the last spike becomes negligible, spike threshold crossing is caused by input variance around a steady state and spiking is Poisson. In integrate-and-fire neurons matched to cortical cell physiology, steady-state behavior is predominant, and ISIs are highly variable at all physiological firing rates and for a wide range of inhibitory and excitatory inputs. IS - 5 JF - Neural Comput SN - 0899-7667 AD - Keck Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco 94143, USA. EP - 983 TI - Physiological gain leads to high ISI variability in a simple model of a cortical regular spiking cell. VL - 9 SP - 971 KW - cell-models KW - control-theory KW - neuro-coding KW - neuro-computation KW - neuro-spike KW - neuro-sync KW - neuro-timing KW - neuroplasticity KW - time-course KW - time-dynamics AU - Troyer, TW AU - Miller, KD PY - 1997/07/01/ UR - http://neco.mitpress.org/cgi/content/abstract/9/5/971 ER -