Optical Imaging of Neuronal Populations During Decision-Making Export

@article{citeulike:120031, abstract = {We investigated decision-making in the leech nervous system by stimulating identical sensory inputs that sometimes elicit crawling and other times swimming. Neuronal populations were monitored with voltage-sensitive dyes after each stimulus. By quantifying the discrimination time of each neuron, we found single neurons that discriminate before the two behaviors are evident. We used principal component analysis and linear discriminant analysis to find populations of neurons that discriminated earlier than any single neuron. The analysis highlighted the neuron cell 208. Hyperpolarizing cell 208 during a stimulus biases the leech to swim; depolarizing it biases the leech to crawl or to delay swimming. 10.1126/science.1103736}, address = {Division of Biological Sciences, University of California-San Diego, La Jolla, CA 92093-0357, USA.}, author = {Briggman, K. L. and Abarbanel, H. D. I. and Kristan, W. B.}, citeulike-article-id = {120031}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1103736}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/307/5711/896}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15705844}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15705844}, day = {11}, doi = {10.1126/science.1103736}, issn = {1095-9203}, journal = {Science}, keywords = {decisionmaking, imaging, leech}, month = {February}, number = {5711}, pages = {896--901}, posted-at = {2009-07-23 10:22:43}, priority = {2}, title = {Optical Imaging of Neuronal Populations During Decision-Making}, url = {http://dx.doi.org/10.1126/science.1103736}, volume = {307}, year = {2005} }

TY - JOUR ID - citeulike:120031 L3 - citeulike-article-id:120031 N2 - We investigated decision-making in the leech nervous system by stimulating identical sensory inputs that sometimes elicit crawling and other times swimming. Neuronal populations were monitored with voltage-sensitive dyes after each stimulus. By quantifying the discrimination time of each neuron, we found single neurons that discriminate before the two behaviors are evident. We used principal component analysis and linear discriminant analysis to find populations of neurons that discriminated earlier than any single neuron. The analysis highlighted the neuron cell 208. Hyperpolarizing cell 208 during a stimulus biases the leech to swim; depolarizing it biases the leech to crawl or to delay swimming. 10.1126/science.1103736 IS - 5711 JF - Science SN - 1095-9203 AD - Division of Biological Sciences, University of California-San Diego, La Jolla, CA 92093-0357, USA. EP - 901 TI - Optical Imaging of Neuronal Populations During Decision-Making VL - 307 SP - 896 KW - decisionmaking KW - imaging KW - leech AU - Briggman, KL AU - Abarbanel, HDI AU - Kristan, WB PY - 2005/02/11/ UR - http://dx.doi.org/10.1126/science.1103736 ER -