Genetically Determined Differences in Learning from Errors Export

@article{citeulike:2073765, abstract = {The role of dopamine in monitoring negative action outcomes and feedback-based learning was tested in a neuroimaging study in humans grouped according to the dopamine D2 receptor gene polymorphism DRD2-TAQ-IA. In a probabilistic learning task, A1-allele carriers with reduced dopamine D2 receptor densities learned to avoid actions with negative consequences less efficiently. Their posterior medial frontal cortex (pMFC), involved in feedback monitoring, responded less to negative feedback than others' did. Dynamically changing interactions between pMFC and hippocampus found to underlie feedback-based learning were reduced in A1-allele carriers. This demonstrates that learning from errors requires dopaminergic signaling. Dopamine D2 receptor reduction seems to decrease sensitivity to negative action consequences, which may explain an increased risk of developing addictive behaviors in A1-allele carriers. 10.1126/science.1145044}, author = {Klein, Tilmann A. and Neumann, Jane and Reuter, Martin and Hennig, Jurgen and von Cramon, D. Yves and Ullsperger, Markus}, citeulike-article-id = {2073765}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1145044}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/318/5856/1642}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18063800}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18063800}, day = {7}, doi = {10.1126/science.1145044}, journal = {Science}, keywords = {d2receptor, dopamine, human, learningmemory}, month = {December}, number = {5856}, pages = {1642--1645}, posted-at = {2009-07-27 03:41:05}, priority = {2}, title = {Genetically Determined Differences in Learning from Errors}, url = {http://dx.doi.org/10.1126/science.1145044}, volume = {318}, year = {2007} }

TY - JOUR ID - citeulike:2073765 L3 - citeulike-article-id:2073765 N2 - The role of dopamine in monitoring negative action outcomes and feedback-based learning was tested in a neuroimaging study in humans grouped according to the dopamine D2 receptor gene polymorphism DRD2-TAQ-IA. In a probabilistic learning task, A1-allele carriers with reduced dopamine D2 receptor densities learned to avoid actions with negative consequences less efficiently. Their posterior medial frontal cortex (pMFC), involved in feedback monitoring, responded less to negative feedback than others' did. Dynamically changing interactions between pMFC and hippocampus found to underlie feedback-based learning were reduced in A1-allele carriers. This demonstrates that learning from errors requires dopaminergic signaling. Dopamine D2 receptor reduction seems to decrease sensitivity to negative action consequences, which may explain an increased risk of developing addictive behaviors in A1-allele carriers. 10.1126/science.1145044 IS - 5856 JF - Science EP - 1645 TI - Genetically Determined Differences in Learning from Errors VL - 318 SP - 1642 KW - d2receptor KW - dopamine KW - human KW - learningmemory AU - Klein, Tilmann AU - Neumann, Jane AU - Reuter, Martin AU - Hennig, Jurgen AU - von Cramon, Yves AU - Ullsperger, Markus PY - 2007/12/07/ UR - http://dx.doi.org/10.1126/science.1145044 ER -