Genetic Dissection of Neural Circuits Export

@article{citeulike:2566282, abstract = {Understanding the principles of information processing in neural circuits requires systematic characterization of the participating cell types and their connections, and the ability to measure and perturb their activity. Genetic approaches promise to bring experimental access to complex neural systems, including genetic stalwarts such as the fly and mouse, but also to nongenetic systems such as primates. Together with anatomical and physiological methods, cell-type-specific expression of protein markers and sensors and transducers will be critical to construct circuit diagrams and to measure the activity of genetically defined neurons. Inactivation and activation of genetically defined cell types will establish causal relationships between activity in specific groups of neurons, circuit function, and animal behavior. Genetic analysis thus promises to reveal the logic of the neural circuits in complex brains that guide behaviors. Here we review progress in the genetic analysis of neural circuits and discuss directions for future research and development.}, address = {Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.}, author = {Luo, Liqun and Callaway, Edward M. and Svoboda, Karel}, citeulike-article-id = {2566282}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2008.01.002}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0896627308000317}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18341986}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18341986}, citeulike-linkout-4 = {http://www.sciencedirect.com/science/article/B6WSS-4S1SWWH-5/2/2c53745f772dab937288085d32bbd148}, day = {13}, doi = {10.1016/j.neuron.2008.01.002}, issn = {08966273}, journal = {Neuron}, keywords = {circuit, drosophila, map, method, review}, month = {March}, number = {5}, pages = {634--660}, posted-at = {2009-11-11 13:57:00}, priority = {2}, title = {Genetic Dissection of Neural Circuits}, url = {http://dx.doi.org/10.1016/j.neuron.2008.01.002}, volume = {57}, year = {2008} }

TY - JOUR ID - citeulike:2566282 L3 - citeulike-article-id:2566282 N2 - Understanding the principles of information processing in neural circuits requires systematic characterization of the participating cell types and their connections, and the ability to measure and perturb their activity. Genetic approaches promise to bring experimental access to complex neural systems, including genetic stalwarts such as the fly and mouse, but also to nongenetic systems such as primates. Together with anatomical and physiological methods, cell-type-specific expression of protein markers and sensors and transducers will be critical to construct circuit diagrams and to measure the activity of genetically defined neurons. Inactivation and activation of genetically defined cell types will establish causal relationships between activity in specific groups of neurons, circuit function, and animal behavior. Genetic analysis thus promises to reveal the logic of the neural circuits in complex brains that guide behaviors. Here we review progress in the genetic analysis of neural circuits and discuss directions for future research and development. IS - 5 JF - Neuron SN - 08966273 AD - Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. EP - 660 TI - Genetic Dissection of Neural Circuits VL - 57 SP - 634 KW - circuit KW - drosophila KW - map KW - method KW - review AU - Luo, Liqun AU - Callaway, Edward AU - Svoboda, Karel PY - 2008/03/13/ UR - http://dx.doi.org/10.1016/j.neuron.2008.01.002 ER -