Selective erasure of a fear memory. Export

@article{citeulike:4170010, abstract = {Memories are thought to be encoded by sparsely distributed groups of neurons. However, identifying the precise neurons supporting a given memory (the memory trace) has been a long-standing challenge. We have shown previously that lateral amygdala (LA) neurons with increased cyclic adenosine monophosphate response element-binding protein (CREB) are preferentially activated by fear memory expression, which suggests that they are selectively recruited into the memory trace. We used an inducible diphtheria-toxin strategy to specifically ablate these neurons. Selectively deleting neurons overexpressing CREB (but not a similar portion of random LA neurons) after learning blocked expression of that fear memory. The resulting memory loss was robust and persistent, which suggests that the memory was permanently erased. These results establish a causal link between a specific neuronal subpopulation and memory expression, thereby identifying critical neurons within the memory trace.}, author = {Han, Jin-Hee H. and Kushner, Steven A. and Yiu, Adelaide P. and Hsiang, Hwa-Lin Liz L. and Buch, Thorsten and Waisman, Ari and Bontempi, Bruno and Neve, Rachael L. and Frankland, Paul W. and Josselyn, Sheena A.}, citeulike-article-id = {4170010}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1164139}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/323/5920/1492}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19286560}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19286560}, day = {13}, doi = {10.1126/science.1164139}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {fear, learningmemory, mouse}, month = {March}, number = {5920}, pages = {1492--1496}, posted-at = {2009-03-19 07:07:11}, priority = {2}, title = {Selective erasure of a fear memory.}, url = {http://dx.doi.org/10.1126/science.1164139}, volume = {323}, year = {2009} }

TY - JOUR ID - citeulike:4170010 L3 - citeulike-article-id:4170010 N2 - Memories are thought to be encoded by sparsely distributed groups of neurons. However, identifying the precise neurons supporting a given memory (the memory trace) has been a long-standing challenge. We have shown previously that lateral amygdala (LA) neurons with increased cyclic adenosine monophosphate response element-binding protein (CREB) are preferentially activated by fear memory expression, which suggests that they are selectively recruited into the memory trace. We used an inducible diphtheria-toxin strategy to specifically ablate these neurons. Selectively deleting neurons overexpressing CREB (but not a similar portion of random LA neurons) after learning blocked expression of that fear memory. The resulting memory loss was robust and persistent, which suggests that the memory was permanently erased. These results establish a causal link between a specific neuronal subpopulation and memory expression, thereby identifying critical neurons within the memory trace. IS - 5920 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 1496 TI - Selective erasure of a fear memory. VL - 323 SP - 1492 KW - fear KW - learningmemory KW - mouse AU - Han, Jin-Hee AU - Kushner, Steven AU - Yiu, Adelaide AU - Hsiang, Hwa-Lin Liz AU - Buch, Thorsten AU - Waisman, Ari AU - Bontempi, Bruno AU - Neve, Rachael AU - Frankland, Paul AU - Josselyn, Sheena PY - 2009/03/13/ UR - http://dx.doi.org/10.1126/science.1164139 ER -