Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity. Export

@article{citeulike:5276486, abstract = {We examined tyrosine hydroxylase (TH-GAL4) expression and anti-TH immunoreactivity in the Drosophila protocerebrum and characterized single cell clones of the TH-GAL4 neurons. Eight clusters of putative dopaminergic neurons were characterized. Neurons in three of the clusters project to the mushroom body neuropil: PAM neurons project to the medial portion of the horizontal lobes; PPL1 neurons project to the vertical lobes, the junction area, the heel and distal peduncle; and PPL2ab neurons project to the calyx. Five types of PPL1 neurons were discovered that innervate different zones of the mushroom body lobes. Functional imaging experiments showed that the dopaminergic processes in four of the zones differ in response properties to odor, electric shock, or following the pairing of odor and electric shock. These results indicate that distinct dopaminergic neurons define separate zones of the mushroom body lobes and are probably involved in different functions. Differences in functional response properties of these neurons suggest that they are involved in different behavioral processes.}, author = {Mao, Z. and Davis, R. L.}, citeulike-article-id = {5276486}, citeulike-linkout-0 = {http://dx.doi.org/10.3389/neuro.04.005.2009}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19597562}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19597562}, doi = {10.3389/neuro.04.005.2009}, issn = {1662-5110}, journal = {Frontiers in neural circuits}, keywords = {circuit, dopamine, drosophila, imaging, map}, posted-at = {2009-07-27 03:43:55}, priority = {2}, title = {Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity.}, url = {http://dx.doi.org/10.3389/neuro.04.005.2009}, volume = {3}, year = {2009} }

TY - JOUR ID - citeulike:5276486 L3 - citeulike-article-id:5276486 N2 - We examined tyrosine hydroxylase (TH-GAL4) expression and anti-TH immunoreactivity in the Drosophila protocerebrum and characterized single cell clones of the TH-GAL4 neurons. Eight clusters of putative dopaminergic neurons were characterized. Neurons in three of the clusters project to the mushroom body neuropil: PAM neurons project to the medial portion of the horizontal lobes; PPL1 neurons project to the vertical lobes, the junction area, the heel and distal peduncle; and PPL2ab neurons project to the calyx. Five types of PPL1 neurons were discovered that innervate different zones of the mushroom body lobes. Functional imaging experiments showed that the dopaminergic processes in four of the zones differ in response properties to odor, electric shock, or following the pairing of odor and electric shock. These results indicate that distinct dopaminergic neurons define separate zones of the mushroom body lobes and are probably involved in different functions. Differences in functional response properties of these neurons suggest that they are involved in different behavioral processes. JF - Frontiers in neural circuits SN - 1662-5110 TI - Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity. VL - 3 KW - circuit KW - dopamine KW - drosophila KW - imaging KW - map AU - Mao, Z AU - Davis, RL PY - 2009/// UR - http://dx.doi.org/10.3389/neuro.04.005.2009 ER -