Immunogenicity in humans of an edible vaccine for hepatitis B Export

@article{citeulike:2152559, abstract = {A double-blind placebo-controlled clinical trial evaluated the immunogenicity of hepatitis B surface antigen (HBsAg) expressed in potatoes and delivered orally to previously vaccinated individuals. The potatoes accumulated HBsAg at {approx}8.5 {micro}g/g of potato tuber, and doses of 100 g of tuber were administered by ingestion. The correlate of protection for hepatitis B virus, a nonenteric pathogen, is blood serum antibody titers against HBsAg. After volunteers ate uncooked potatoes, serum anti-HBsAg titers increased in 10 of 16 volunteers (62.5\%) who ate three doses of potatoes; in 9 of 17 volunteers (52.9\%) who ate two doses of transgenic potatoes; and in none of the volunteers who ate nontransgenic potatoes. These results were achieved without the coadministration of a mucosal adjuvant or the need for buffering stomach pH. We conclude that a plant-derived orally delivered vaccine for prevention of hepatitis B virus should be considered as a viable component of a global immunization program. 10.1073/pnas.0409899102}, author = {Thanavala, Yasmin and Mahoney, Martin and Pal, Sribani and Scott, Adrienne and Richter, Liz and Natarajan, Nachimuthu and Goodwin, Patti and Arntzen, Charles J. and Mason, Hugh S.}, citeulike-article-id = {2152559}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0409899102}, citeulike-linkout-1 = {http://www.pnas.org/cgi/content/abstract/102/9/3378}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15728371}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15728371}, day = {1}, doi = {10.1073/pnas.0409899102}, journal = {Proceedings of the National Academy of Sciences}, keywords = {hepatitis\_b, transgenic}, month = {March}, number = {9}, pages = {3378--3382}, posted-at = {2007-12-20 17:47:40}, priority = {2}, title = {Immunogenicity in humans of an edible vaccine for hepatitis B}, url = {http://dx.doi.org/10.1073/pnas.0409899102}, volume = {102}, year = {2005} }

TY - JOUR ID - citeulike:2152559 L3 - citeulike-article-id:2152559 N2 - A double-blind placebo-controlled clinical trial evaluated the immunogenicity of hepatitis B surface antigen (HBsAg) expressed in potatoes and delivered orally to previously vaccinated individuals. The potatoes accumulated HBsAg at {approx}8.5 {micro}g/g of potato tuber, and doses of 100 g of tuber were administered by ingestion. The correlate of protection for hepatitis B virus, a nonenteric pathogen, is blood serum antibody titers against HBsAg. After volunteers ate uncooked potatoes, serum anti-HBsAg titers increased in 10 of 16 volunteers (62.5%) who ate three doses of potatoes; in 9 of 17 volunteers (52.9%) who ate two doses of transgenic potatoes; and in none of the volunteers who ate nontransgenic potatoes. These results were achieved without the coadministration of a mucosal adjuvant or the need for buffering stomach pH. We conclude that a plant-derived orally delivered vaccine for prevention of hepatitis B virus should be considered as a viable component of a global immunization program. 10.1073/pnas.0409899102 IS - 9 JF - Proceedings of the National Academy of Sciences EP - 3382 TI - Immunogenicity in humans of an edible vaccine for hepatitis B VL - 102 SP - 3378 KW - hepatitis_b KW - transgenic AU - Thanavala, Yasmin AU - Mahoney, Martin AU - Pal, Sribani AU - Scott, Adrienne AU - Richter, Liz AU - Natarajan, Nachimuthu AU - Goodwin, Patti AU - Arntzen, Charles AU - Mason, Hugh PY - 2005/03/01/ UR - http://dx.doi.org/10.1073/pnas.0409899102 ER -