Inability of outer-surface protein C (OspC)-primed mice to elicit a protective anamnestic immune response to a tick-transmitted challenge of Borrelia burgdorferi Export

@article{citeulike:2164362, abstract = {A one-inoculation regimen of recombinant outer-surface protein C (OspC), which has been demonstrated to elicit protective immunity against a tick-borne challenge of Borrelia burgdorferi, was administered to outbred mice. Following seroconversion, the serum antibody titre against OspC was allowed to wane with time until there was little or no detection of anti-OspC antibodies by immunoblot. The mice were then challenged with an infectious dose of B. burgdorferi by tick transmission. Eleven of 12 OspC-primed mice subsequently became infected by B. burgdorferi, demonstrating that a protective anamnestic response was not generated in these mice following the introduction of infectious OspC-expressing spirochaetes. 10.1099/jmm.0.05068-0}, author = {Gilmore, Robert D. and Bacon, Rendi M. and Carpio, Amber M. and Piesman, Joseph and Dolan, Marc C. and Mbow, Lamine M.}, citeulike-article-id = {2164362}, citeulike-linkout-0 = {http://dx.doi.org/10.1099/jmm.0.05068-0}, citeulike-linkout-1 = {http://jmm.sgmjournals.org/cgi/content/abstract/52/7/551}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/12808075}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=12808075}, day = {1}, doi = {10.1099/jmm.0.05068-0}, journal = {J Med Microbiol}, keywords = {lyme}, month = {July}, number = {7}, pages = {551--556}, posted-at = {2007-12-24 21:34:29}, priority = {5}, title = {Inability of outer-surface protein C (OspC)-primed mice to elicit a protective anamnestic immune response to a tick-transmitted challenge of Borrelia burgdorferi}, url = {http://dx.doi.org/10.1099/jmm.0.05068-0}, volume = {52}, year = {2003} }

TY - JOUR ID - citeulike:2164362 L3 - citeulike-article-id:2164362 N2 - A one-inoculation regimen of recombinant outer-surface protein C (OspC), which has been demonstrated to elicit protective immunity against a tick-borne challenge of Borrelia burgdorferi, was administered to outbred mice. Following seroconversion, the serum antibody titre against OspC was allowed to wane with time until there was little or no detection of anti-OspC antibodies by immunoblot. The mice were then challenged with an infectious dose of B. burgdorferi by tick transmission. Eleven of 12 OspC-primed mice subsequently became infected by B. burgdorferi, demonstrating that a protective anamnestic response was not generated in these mice following the introduction of infectious OspC-expressing spirochaetes. 10.1099/jmm.0.05068-0 IS - 7 JF - J Med Microbiol EP - 556 TI - Inability of outer-surface protein C (OspC)-primed mice to elicit a protective anamnestic immune response to a tick-transmitted challenge of Borrelia burgdorferi VL - 52 SP - 551 KW - lyme AU - Gilmore, Robert AU - Bacon, Rendi AU - Carpio, Amber AU - Piesman, Joseph AU - Dolan, Marc AU - Mbow, Lamine PY - 2003/07/01/ UR - http://dx.doi.org/10.1099/jmm.0.05068-0 ER -