Lunasin: a novel cancer preventive seed peptide that modifies chromatin. Export

@article{citeulike:3316392, abstract = {Lunasin is a novel cancer preventive peptide whose efficacy against chemical carcinogens and oncogenes has been demonstrated in mammalian cells and a skin cancer mouse model. In contrast, constitutive expression of the lunasin gene in mammalian cells leads to arrest of cell division and cell death. Isolated and characterized in soy, lunasin peptide is also documented in barley and wheat and is predicted to be present in many more seeds because of its possible role in seed development. Initial studies show that lunasin is bioavailable in mice when orally ingested. Lunasin internalizes into mammalian cells within minutes of exogenous application, and localizes in the nucleus after 18 h. It inhibits acetylation of core histones in mammalian cells but does not affect the growth rate of normal and established cancer cell lines. An epigenetic mechanism of action is proposed whereby lunasin selectively kills cells being transformed or newly transformed cells by binding to deacetylated core histones exposed by the transformation event, disrupting the dynamics of histone acetylation-deacetylation.}, address = {University of California, Department of Nutritional Sciences and Toxicology, 119 Morgan Hall, Berkeley, CA 94720-3104, USA. nitto@nature.berkeley.edu}, author = {de Lumen, B. O.}, citeulike-article-id = {3316392}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18727555}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18727555}, issn = {1060-3271}, journal = {Journal of AOAC International}, keywords = {lunasin}, number = {4}, pages = {932--935}, posted-at = {2008-09-22 16:20:56}, priority = {0}, title = {Lunasin: a novel cancer preventive seed peptide that modifies chromatin.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18727555}, volume = {91}, year = {2008} }

TY - JOUR ID - citeulike:3316392 L3 - citeulike-article-id:3316392 N2 - Lunasin is a novel cancer preventive peptide whose efficacy against chemical carcinogens and oncogenes has been demonstrated in mammalian cells and a skin cancer mouse model. In contrast, constitutive expression of the lunasin gene in mammalian cells leads to arrest of cell division and cell death. Isolated and characterized in soy, lunasin peptide is also documented in barley and wheat and is predicted to be present in many more seeds because of its possible role in seed development. Initial studies show that lunasin is bioavailable in mice when orally ingested. Lunasin internalizes into mammalian cells within minutes of exogenous application, and localizes in the nucleus after 18 h. It inhibits acetylation of core histones in mammalian cells but does not affect the growth rate of normal and established cancer cell lines. An epigenetic mechanism of action is proposed whereby lunasin selectively kills cells being transformed or newly transformed cells by binding to deacetylated core histones exposed by the transformation event, disrupting the dynamics of histone acetylation-deacetylation. IS - 4 JF - Journal of AOAC International SN - 1060-3271 AD - University of California, Department of Nutritional Sciences and Toxicology, 119 Morgan Hall, Berkeley, CA 94720-3104, USA. nitto@nature.berkeley.edu EP - 935 TI - Lunasin: a novel cancer preventive seed peptide that modifies chromatin. VL - 91 SP - 932 KW - lunasin AU - de Lumen, BO PY - 2008///g UR - http://view.ncbi.nlm.nih.gov/pubmed/18727555 ER -