Sodium pumps adapt spike bursting to stimulus statistics. Export

@article{arganda_07_sodium, abstract = {Pump activity is a homeostatic mechanism that maintains ionic gradients. Here we examined whether the slow reduction in excitability induced by sodium-pump activity that has been seen in many neuronal types is also involved in neuronal coding. We took intracellular recordings from a spike-bursting sensory neuron in the leech Hirudo medicinalis in response to naturalistic tactile stimuli with different statistical distributions. We show that regulation of excitability by sodium pumps is necessary for the neuron to make different responses depending on the statistical context of the stimuli. In particular, sodium-pump activity allowed spike-burst sizes and rates to code not for stimulus values per se, but for their ratio with the standard deviation of the stimulus distribution. Modeling further showed that sodium pumps can be a general mechanism of adaptation to statistics on the time scale of 1 min. These results implicate the ubiquitous pump activity in the adaptation of neural codes to statistics.}, address = {[1] Neural Processing Laboratory, Instituto 'Nicol\'{a}s Cabrera' de F\'{\i}sica de Materiales, Facultad de Ciencias, C-XVI. [2] Department of Theoretical Physics, Facultad de Ciencias, C-XI. [3] These authors contributed equally to this work.}, author = {Arganda, Sara and Guantes, Ra\'{u}l and de Polavieja, Gonzalo G. G.}, citeulike-article-id = {1789166}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nn1982}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nn1982}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17906619}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17906619}, citeulike-linkout-4 = {http://dx.doi.org/http://dx.doi.org/10.1038/nn1982}, citeulike-linkout-5 = {http://dx.doi.org/10.1038/nn1982}, day = {30}, doi = {10.1038/nn1982}, issn = {1097-6256}, journal = {Nature Neuroscience}, keywords = {adaptation, channel, coding, hh, leech, model}, month = {September}, pdf = {arganda\_07\_sodium.pdf}, posted-at = {2007-11-01 15:02:32}, priority = {2}, title = {Sodium pumps adapt spike bursting to stimulus statistics.}, url = {http://dx.doi.org/10.1038/nn1982}, year = {2007} }

TY - JOUR ID - arganda_07_sodium L3 - citeulike-article-id:1789166 N2 - Pump activity is a homeostatic mechanism that maintains ionic gradients. Here we examined whether the slow reduction in excitability induced by sodium-pump activity that has been seen in many neuronal types is also involved in neuronal coding. We took intracellular recordings from a spike-bursting sensory neuron in the leech Hirudo medicinalis in response to naturalistic tactile stimuli with different statistical distributions. We show that regulation of excitability by sodium pumps is necessary for the neuron to make different responses depending on the statistical context of the stimuli. In particular, sodium-pump activity allowed spike-burst sizes and rates to code not for stimulus values per se, but for their ratio with the standard deviation of the stimulus distribution. Modeling further showed that sodium pumps can be a general mechanism of adaptation to statistics on the time scale of 1 min. These results implicate the ubiquitous pump activity in the adaptation of neural codes to statistics. JF - Nature Neuroscience SN - 1097-6256 AD - [1] Neural Processing Laboratory, Instituto 'Nicolás Cabrera' de Física de Materiales, Facultad de Ciencias, C-XVI. [2] Department of Theoretical Physics, Facultad de Ciencias, C-XI. [3] These authors contributed equally to this work. TI - Sodium pumps adapt spike bursting to stimulus statistics. KW - adaptation KW - channel KW - coding KW - hh KW - leech KW - model AU - Arganda, Sara AU - Guantes, Raúl AU - de Polavieja, Gonzalo PY - 2007/September/30/ UR - http://dx.doi.org/10.1038/nn1982 ER -