Attention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus. Export

@article{Muzzio_2009_attention, abstract = {A key question in the analysis of hippocampal memory relates to how attention modulates the encoding and long-term retrieval of spatial and nonspatial representations in this region. To address this question, we recorded from single cells over a period of 5 days in the CA1 region of the dorsal hippocampus while mice acquired one of two goal-oriented tasks. These tasks required the animals to find a hidden food reward by attending to either the visuospatial environment or a particular odor presented in shifting spatial locations. Attention to the visuospatial environment increased the stability of visuospatial representations and phase locking to gamma oscillations--a form of neuronal synchronization thought to underlie the attentional mechanism necessary for processing task-relevant information. Attention to a spatially shifting olfactory cue compromised the stability of place fields and increased the stability of reward-associated odor representations, which were most consistently retrieved during periods of sniffing and digging when animals were restricted to the cup locations. Together, these results suggest that attention selectively modulates the encoding and retrieval of hippocampal representations by enhancing physiological responses to task-relevant information.}, author = {Muzzio, I. A. and Levita, L. and Kulkarni, J. and Monaco, J. and Kentros, C. and Stead, M. and Abbott, L. F. and Kandel, E. R.}, citeulike-article-id = {5031644}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pbio.1000140}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19564903}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19564903}, day = {30}, doi = {10.1371/journal.pbio.1000140}, issn = {1545-7885}, journal = {PLoS biology}, keywords = {attention, behavior, coding, olfactory, visual}, month = {June}, number = {6}, pages = {e1000140+}, posted-at = {2009-07-01 10:33:05}, priority = {2}, publisher = {Public Library of Science}, title = {Attention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus.}, url = {http://dx.doi.org/10.1371/journal.pbio.1000140}, volume = {7}, year = {2009} }

TY - JOUR ID - Muzzio_2009_attention L3 - citeulike-article-id:5031644 N2 - A key question in the analysis of hippocampal memory relates to how attention modulates the encoding and long-term retrieval of spatial and nonspatial representations in this region. To address this question, we recorded from single cells over a period of 5 days in the CA1 region of the dorsal hippocampus while mice acquired one of two goal-oriented tasks. These tasks required the animals to find a hidden food reward by attending to either the visuospatial environment or a particular odor presented in shifting spatial locations. Attention to the visuospatial environment increased the stability of visuospatial representations and phase locking to gamma oscillations--a form of neuronal synchronization thought to underlie the attentional mechanism necessary for processing task-relevant information. Attention to a spatially shifting olfactory cue compromised the stability of place fields and increased the stability of reward-associated odor representations, which were most consistently retrieved during periods of sniffing and digging when animals were restricted to the cup locations. Together, these results suggest that attention selectively modulates the encoding and retrieval of hippocampal representations by enhancing physiological responses to task-relevant information. IS - 6 JF - PLoS biology SN - 1545-7885 TI - Attention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus. PB - Public Library of Science VL - 7 SP - e1000140 KW - attention KW - behavior KW - coding KW - olfactory KW - visual AU - Muzzio, IA AU - Levita, L AU - Kulkarni, J AU - Monaco, J AU - Kentros, C AU - Stead, M AU - Abbott, LF AU - Kandel, ER PY - 2009/June/30/ UR - http://dx.doi.org/10.1371/journal.pbio.1000140 ER -