Synaptic Integration in Tuft Dendrites of Layer 5 Pyramidal Neurons: A New Unifying Principle Export

@article{Larkum_2009_synaptic, abstract = {Tuft dendrites are the main target for feedback inputs innervating neocortical layer 5 pyramidal neurons, but their properties remain obscure. We report the existence of N-methyl-D-aspartate (NMDA) spikes in the fine distal tuft dendrites that otherwise did not support the initiation of calcium spikes. Both direct measurements and computer simulations showed that NMDA spikes are the dominant mechanism by which distal synaptic input leads to firing of the neuron and provide the substrate for complex parallel processing of top-down input arriving at the tuft. These data lead to a new unifying view of integration in pyramidal neurons in which all fine dendrites, basal and tuft, integrate inputs locally through the recruitment of NMDA receptor channels relative to the fixed apical calcium and axosomatic sodium integration points. 10.1126/science.1171958}, author = {Larkum, Matthew E. and Nevian, Thomas and Sandler, Maya and Polsky, Alon and Schiller, Jackie}, citeulike-article-id = {5397196}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1171958}, citeulike-linkout-1 = {http://www.sciencemag.org/content/325/5941/756.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/325/5941/756.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/325/5941/756}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/19661433}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=19661433}, day = {7}, doi = {10.1126/science.1171958}, issn = {1095-9203}, journal = {Science}, keywords = {cortex, dendrite}, month = {August}, number = {5941}, pages = {756--760}, pdf = {larkum\_09\_synaptic.pdf}, posted-at = {2009-08-08 18:40:22}, priority = {2}, title = {Synaptic Integration in Tuft Dendrites of Layer 5 Pyramidal Neurons: A New Unifying Principle}, url = {http://dx.doi.org/10.1126/science.1171958}, volume = {325}, year = {2009} }

TY - JOUR ID - Larkum_2009_synaptic L3 - citeulike-article-id:5397196 N2 - Tuft dendrites are the main target for feedback inputs innervating neocortical layer 5 pyramidal neurons, but their properties remain obscure. We report the existence of N-methyl-D-aspartate (NMDA) spikes in the fine distal tuft dendrites that otherwise did not support the initiation of calcium spikes. Both direct measurements and computer simulations showed that NMDA spikes are the dominant mechanism by which distal synaptic input leads to firing of the neuron and provide the substrate for complex parallel processing of top-down input arriving at the tuft. These data lead to a new unifying view of integration in pyramidal neurons in which all fine dendrites, basal and tuft, integrate inputs locally through the recruitment of NMDA receptor channels relative to the fixed apical calcium and axosomatic sodium integration points. 10.1126/science.1171958 IS - 5941 JF - Science SN - 1095-9203 EP - 760 TI - Synaptic Integration in Tuft Dendrites of Layer 5 Pyramidal Neurons: A New Unifying Principle VL - 325 SP - 756 KW - cortex KW - dendrite AU - Larkum, Matthew AU - Nevian, Thomas AU - Sandler, Maya AU - Polsky, Alon AU - Schiller, Jackie PY - 2009/August/07/ UR - http://dx.doi.org/10.1126/science.1171958 ER -