Cortical Firing and Sleep Homeostasis Export

@article{vyazovskiy_09_cortical, abstract = {The need to sleep grows with the duration of wakefulness and dissipates with time spent asleep, a process called sleep homeostasis. What are the consequences of staying awake on brain cells, and why is sleep needed? Surprisingly, we do not know whether the firing of cortical neurons is affected by how long an animal has been awake or asleep. Here, we found that after sustained wakefulness cortical neurons fire at higher frequencies in all behavioral states. During early NREM sleep after sustained wakefulness, periods of population activity (ON) are short, frequent, and associated with synchronous firing, while periods of neuronal silence are long and frequent. After sustained sleep, firing rates and synchrony decrease, while the duration of ON periods increases. Changes in firing patterns in NREM sleep correlate with changes in slow-wave activity, a marker of sleep homeostasis. Thus, the systematic increase of firing during wakefulness is counterbalanced by staying asleep.}, author = {Vyazovskiy, Vladyslav V. and Olcese, Umberto and Lazimy, Yaniv M. and Faraguna, Ugo and Esser, Steve K. and Williams, Justin C. and Cirelli, Chiara and Tononi, Giulio}, citeulike-article-id = {5870680}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2009.08.024}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0896627309006370}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19778514}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19778514}, day = {24}, doi = {10.1016/j.neuron.2009.08.024}, issn = {1097-4199}, journal = {Neuron}, keywords = {oscillation, rem, sleep}, month = {September}, number = {6}, pages = {865--878}, posted-at = {2009-10-27 08:38:25}, priority = {2}, title = {Cortical Firing and Sleep Homeostasis}, url = {http://dx.doi.org/10.1016/j.neuron.2009.08.024}, volume = {63}, year = {2009} }

TY - JOUR ID - vyazovskiy_09_cortical L3 - citeulike-article-id:5870680 N2 - The need to sleep grows with the duration of wakefulness and dissipates with time spent asleep, a process called sleep homeostasis. What are the consequences of staying awake on brain cells, and why is sleep needed? Surprisingly, we do not know whether the firing of cortical neurons is affected by how long an animal has been awake or asleep. Here, we found that after sustained wakefulness cortical neurons fire at higher frequencies in all behavioral states. During early NREM sleep after sustained wakefulness, periods of population activity (ON) are short, frequent, and associated with synchronous firing, while periods of neuronal silence are long and frequent. After sustained sleep, firing rates and synchrony decrease, while the duration of ON periods increases. Changes in firing patterns in NREM sleep correlate with changes in slow-wave activity, a marker of sleep homeostasis. Thus, the systematic increase of firing during wakefulness is counterbalanced by staying asleep. IS - 6 JF - Neuron SN - 1097-4199 EP - 878 TI - Cortical Firing and Sleep Homeostasis VL - 63 SP - 865 KW - oscillation KW - rem KW - sleep AU - Vyazovskiy, Vladyslav AU - Olcese, Umberto AU - Lazimy, Yaniv AU - Faraguna, Ugo AU - Esser, Steve AU - Williams, Justin AU - Cirelli, Chiara AU - Tononi, Giulio PY - 2009/September/24/ UR - http://dx.doi.org/10.1016/j.neuron.2009.08.024 ER -