Reproducibility and variability in neural spike trains. Export

@article{Ruyter_1997_reproducibility, abstract = {To provide information about dynamic sensory stimuli, the pattern of action potentials in spiking neurons must be variable. To ensure reliability these variations must be related, reproducibly, to the stimulus. For H1, a motion-sensitive neuron in the fly's visual system, constant-velocity motion produces irregular spike firing patterns, and spike counts typically have a variance comparable to the mean, for cells in the mammalian cortex. But more natural, time-dependent input signals yield patterns of spikes that are much more reproducible, both in terms of timing and of counting precision. Variability and reproducibility are quantified with ideas from information theory, and measured spike sequences in H1 carry more than twice the amount of information they would if they followed the variance-mean relation seen with constant inputs. Thus, models that may accurately account for the neural response to static stimuli can significantly underestimate the reliability of signal transfer under more natural conditions.}, address = {NEC Research Institute, 4 Independence Way, Princeton, NJ 08540, USA.}, author = {Ruyter, De and Lewen, G. D. and Strong, S. P. and Koberle, R. and Bialek, W.}, citeulike-article-id = {90467}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.275.5307.1805}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/275/5307/1805?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&searchid=1&FIRSTINDEX=0&volume=275&firstpage=1805&resourcetype=HWCIT}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/9065407}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=9065407}, citeulike-linkout-4 = {http://dx.doi.org/http://dx.doi.org/10.1126/science.275.5307.1805}, citeulike-linkout-5 = {http://dx.doi.org/10.1126/science.275.5307.1805}, day = {21}, doi = {10.1126/science.275.5307.1805}, issn = {0036-8075}, journal = {Science}, keywords = {coding, fly, h1, noise, precision, visual}, month = {March}, number = {5307}, pages = {1805--1808}, pdf = {ruyter\_97\_reproducibility.pdf}, posted-at = {2009-01-04 11:10:43}, priority = {2}, title = {Reproducibility and variability in neural spike trains.}, url = {http://dx.doi.org/10.1126/science.275.5307.1805}, volume = {275}, year = {1997} }

TY - JOUR ID - Ruyter_1997_reproducibility L3 - citeulike-article-id:90467 N2 - To provide information about dynamic sensory stimuli, the pattern of action potentials in spiking neurons must be variable. To ensure reliability these variations must be related, reproducibly, to the stimulus. For H1, a motion-sensitive neuron in the fly's visual system, constant-velocity motion produces irregular spike firing patterns, and spike counts typically have a variance comparable to the mean, for cells in the mammalian cortex. But more natural, time-dependent input signals yield patterns of spikes that are much more reproducible, both in terms of timing and of counting precision. Variability and reproducibility are quantified with ideas from information theory, and measured spike sequences in H1 carry more than twice the amount of information they would if they followed the variance-mean relation seen with constant inputs. Thus, models that may accurately account for the neural response to static stimuli can significantly underestimate the reliability of signal transfer under more natural conditions. IS - 5307 JF - Science SN - 0036-8075 AD - NEC Research Institute, 4 Independence Way, Princeton, NJ 08540, USA. EP - 1808 TI - Reproducibility and variability in neural spike trains. VL - 275 SP - 1805 KW - coding KW - fly KW - h1 KW - noise KW - precision KW - visual AU - Ruyter, De AU - Lewen, GD AU - Strong, SP AU - Koberle, R AU - Bialek, W PY - 1997/March/21/ UR - http://dx.doi.org/10.1126/science.275.5307.1805 ER -