Qualitative and quantitative assessment of the benefit-risk ratio of medium potency topical corticosteroids in vitro and in vivo: characterisation of drugs with an increased benefit-risk ratio. Export

@article{citeulike:3259745, abstract = {Corticosteroids are widely used for the treatment of inflammatory skin disorders. However, systemic and local adverse drug reactions, especially skin atrophy, are potential complications that limit their use. Several attempts have been made to increase the safety of topical corticosteroid treatment, including new application schedules, special vehicles and new agents. In particular, the group of hydrocortisone and prednisolone double esters, with prednicarbate as the first and most often prescribed representative, seem to be equipotent alternatives to the gold standard betamethasone 17-valerate with respect to anti-inflammatory activity. At the same time, these new agents induce less skin atrophy, which may result from a unique skin metabolism and a specific influence on the cytokine network in the epidermis and dermis. On the basis of these effects, a new approach to in vitro quantification of the benefit-risk ratio has been developed. As already suggested by investigations in human volunteers, the benefit-risk ratio of the new compounds appears to be increased. Therefore, recent research has focused on drugs that selectively modulate cytokine release.}, address = {Department of Dermatology, Ludwig-Maximilians-Universit\"{a}t, Munich, Germany.}, author = {Schackert, C. and Korting, H. C. and Sch\"{a}fer-Korting, M.}, citeulike-article-id = {3259745}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18034533}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18034533}, issn = {1173-8804}, journal = {BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy}, keywords = {real\_option}, month = {April}, number = {4}, pages = {267--277}, posted-at = {2008-09-15 05:28:27}, priority = {2}, title = {Qualitative and quantitative assessment of the benefit-risk ratio of medium potency topical corticosteroids in vitro and in vivo: characterisation of drugs with an increased benefit-risk ratio.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18034533}, volume = {13}, year = {2000} }

TY - JOUR ID - citeulike:3259745 L3 - citeulike-article-id:3259745 N2 - Corticosteroids are widely used for the treatment of inflammatory skin disorders. However, systemic and local adverse drug reactions, especially skin atrophy, are potential complications that limit their use. Several attempts have been made to increase the safety of topical corticosteroid treatment, including new application schedules, special vehicles and new agents. In particular, the group of hydrocortisone and prednisolone double esters, with prednicarbate as the first and most often prescribed representative, seem to be equipotent alternatives to the gold standard betamethasone 17-valerate with respect to anti-inflammatory activity. At the same time, these new agents induce less skin atrophy, which may result from a unique skin metabolism and a specific influence on the cytokine network in the epidermis and dermis. On the basis of these effects, a new approach to in vitro quantification of the benefit-risk ratio has been developed. As already suggested by investigations in human volunteers, the benefit-risk ratio of the new compounds appears to be increased. Therefore, recent research has focused on drugs that selectively modulate cytokine release. IS - 4 JF - BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy SN - 1173-8804 AD - Department of Dermatology, Ludwig-Maximilians-Universität, Munich, Germany. EP - 277 TI - Qualitative and quantitative assessment of the benefit-risk ratio of medium potency topical corticosteroids in vitro and in vivo: characterisation of drugs with an increased benefit-risk ratio. VL - 13 SP - 267 KW - real_option AU - Schackert, C AU - Korting, HC AU - Schäfer-Korting, M PY - 2000/04// UR - http://view.ncbi.nlm.nih.gov/pubmed/18034533 ER -