Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4. Export

@article{citeulike:5288610, abstract = {We observed that Lgr4K5 KO mice had sparse head hair and focal alopecia behind their ears, as observed in tabby (Eda) and downless (Edar) mice, which are models of the human genetic disorder hypohidrotic (anhidrotic) ectodermal dysplasia (HED). Lgr4-deficient mice showed partial impairment in hair follicle development with reduced expression of Edar, Lef1, and Shh, which were essential for hair follicle morphogenesis, in the epidermis. Immunohistochemical analysis of Lgr4-/- mice epidermis using shh antibody showed reduced numbers of hair placodes, and we also detected higher phosphorylation of Smad1/5/8, which is required to suppress normal hair follicle induction. We suspected that Lgr4 might be a novel gene class regulating the development of hair follicles.}, author = {Mohri, Y. and Kato, S. and Umezawa, A. and Okuyama, R. and Nishimori, K.}, citeulike-article-id = {5288610}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/dvdy.21639}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18651655}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18651655}, doi = {10.1002/dvdy.21639}, issn = {1058-8388}, journal = {Developmental dynamics : an official publication of the American Association of Anatomists}, keywords = {edar, hair}, month = {August}, number = {8}, pages = {2235--2242}, posted-at = {2009-07-28 09:39:31}, priority = {2}, title = {Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4.}, url = {http://dx.doi.org/10.1002/dvdy.21639}, volume = {237}, year = {2008} }

TY - JOUR ID - citeulike:5288610 L3 - citeulike-article-id:5288610 N2 - We observed that Lgr4K5 KO mice had sparse head hair and focal alopecia behind their ears, as observed in tabby (Eda) and downless (Edar) mice, which are models of the human genetic disorder hypohidrotic (anhidrotic) ectodermal dysplasia (HED). Lgr4-deficient mice showed partial impairment in hair follicle development with reduced expression of Edar, Lef1, and Shh, which were essential for hair follicle morphogenesis, in the epidermis. Immunohistochemical analysis of Lgr4-/- mice epidermis using shh antibody showed reduced numbers of hair placodes, and we also detected higher phosphorylation of Smad1/5/8, which is required to suppress normal hair follicle induction. We suspected that Lgr4 might be a novel gene class regulating the development of hair follicles. IS - 8 JF - Developmental dynamics : an official publication of the American Association of Anatomists SN - 1058-8388 EP - 2242 TI - Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4. VL - 237 SP - 2235 KW - edar KW - hair AU - Mohri, Y AU - Kato, S AU - Umezawa, A AU - Okuyama, R AU - Nishimori, K PY - 2008/08// UR - http://dx.doi.org/10.1002/dvdy.21639 ER -