Controlling hair follicle signaling pathways through polyubiquitination. Export

@article{citeulike:5289002, abstract = {Hair follicle development and maintenance require precise reciprocal signaling interactions between the epithelium and underlying dermis. Three major developmental signaling pathways, Wnt, Sonic hedgehog, and NF-kappaB/Edar, are indispensable for this process and, when aberrantly activated, can lead to skin and appendage neoplasms. Recent data point to protein polyubiquitination as playing a central role in regulating the timing, duration, and location of signaling. Here we review how polyubiquitination regulates the stability and interaction of key signaling components that control hair follicle development and regeneration.}, author = {Huntzicker, E. G. and Oro, A. E.}, citeulike-article-id = {5289002}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/sj.jid.5700957}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18408747}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18408747}, doi = {10.1038/sj.jid.5700957}, issn = {1523-1747}, journal = {The Journal of investigative dermatology}, keywords = {edar, hair}, month = {May}, number = {5}, pages = {1081--1087}, posted-at = {2009-07-28 10:15:41}, priority = {2}, title = {Controlling hair follicle signaling pathways through polyubiquitination.}, url = {http://dx.doi.org/10.1038/sj.jid.5700957}, volume = {128}, year = {2008} }

TY - JOUR ID - citeulike:5289002 L3 - citeulike-article-id:5289002 N2 - Hair follicle development and maintenance require precise reciprocal signaling interactions between the epithelium and underlying dermis. Three major developmental signaling pathways, Wnt, Sonic hedgehog, and NF-kappaB/Edar, are indispensable for this process and, when aberrantly activated, can lead to skin and appendage neoplasms. Recent data point to protein polyubiquitination as playing a central role in regulating the timing, duration, and location of signaling. Here we review how polyubiquitination regulates the stability and interaction of key signaling components that control hair follicle development and regeneration. IS - 5 JF - The Journal of investigative dermatology SN - 1523-1747 EP - 1087 TI - Controlling hair follicle signaling pathways through polyubiquitination. VL - 128 SP - 1081 KW - edar KW - hair AU - Huntzicker, EG AU - Oro, AE PY - 2008/05// UR - http://dx.doi.org/10.1038/sj.jid.5700957 ER -