Virulence and resistance in malaria: who drives the outcome of the infection? Export

@article{citeulike:1296742, abstract = {Theoretical and experimental studies have established the dynamic nature of virulence and that, like all traits, it has evolved. Understanding parasite evolution offers a conceptual framework for diverse fields and can contribute greatly to decision-making in disease control. Recently, Grech et al. investigated the effects of host genotype-by-parasite genotype interactions on the expression of virulence in an artificial rodent-malaria system. They found that both parasite and host effects explained most of the variance in the virulence, resistance and transmission potential. These findings are a major contribution to the emerging debate on the pros and cons of a coevolutionary approach of virulence evolution; they also hold great potential for more effective control strategies.}, address = {G\'{e}n\'{e}tique et Evolution des Maladies Infectieuses, UMR CNRS/IRD 2724, IRD, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France.}, author = {Lef\`{e}vre, Thierry and Sanchez, Marta and Ponton, Fleur and Hughes, David and Thomas, Fr\'{e}d\'{e}ric}, citeulike-article-id = {1296742}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.pt.2007.04.012}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17493874}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17493874}, day = {8}, doi = {10.1016/j.pt.2007.04.012}, issn = {1471-4922}, journal = {Trends Parasitol}, keywords = {evolution}, month = {May}, posted-at = {2007-05-15 09:58:43}, priority = {2}, title = {Virulence and resistance in malaria: who drives the outcome of the infection?}, url = {http://dx.doi.org/10.1016/j.pt.2007.04.012}, year = {2007} }

TY - JOUR ID - citeulike:1296742 L3 - citeulike-article-id:1296742 N2 - Theoretical and experimental studies have established the dynamic nature of virulence and that, like all traits, it has evolved. Understanding parasite evolution offers a conceptual framework for diverse fields and can contribute greatly to decision-making in disease control. Recently, Grech et al. investigated the effects of host genotype-by-parasite genotype interactions on the expression of virulence in an artificial rodent-malaria system. They found that both parasite and host effects explained most of the variance in the virulence, resistance and transmission potential. These findings are a major contribution to the emerging debate on the pros and cons of a coevolutionary approach of virulence evolution; they also hold great potential for more effective control strategies. JF - Trends Parasitol SN - 1471-4922 AD - Génétique et Evolution des Maladies Infectieuses, UMR CNRS/IRD 2724, IRD, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France. TI - Virulence and resistance in malaria: who drives the outcome of the infection? KW - evolution AU - Lefèvre, Thierry AU - Sanchez, Marta AU - Ponton, Fleur AU - Hughes, David AU - Thomas, Frédéric PY - 2007/05/08/ UR - http://dx.doi.org/10.1016/j.pt.2007.04.012 ER -