Adenovirus 5 and 35 vectors expressing Plasmodium falciparum circumsporozoite surface protein elicit potent antigen-specific cellular IFN-gamma and antibody responses in mice. Export

@article{citeulike:2775368, abstract = {Falciparum malaria vaccine candidates have been developed using recombinant, replication-deficient serotype 5 and 35 adenoviruses (Ad5, Ad35) encoding the Plasmodium falciparum circumsporozoite surface protein (CSP) (Ad5.CS, Ad35.CS) (Crucell Holland BV, Leiden, The Netherlands). To evaluate the immunogenicity of these constructs, BALB/cJ mice were immunized twice with either Ad5.CS, Ad35.CS, empty Ad5-vector (eAd5), empty Ad35 vector (eAd35), or saline. Another group received the CSP-based RTS,S malaria vaccine formulated in the proprietary Adjuvant System AS01B (GlaxoSmithKline Biologicals, Rixensart, Belgium). Here we report that Ad5.CS, Ad35.CS, and RTS,S/AS01B, elicited both cellular and serologic CSP antigen-specific responses in mice. These adenoviral vectors induce strong malaria-specific immunity and warrant further evaluation.}, address = {Division of Malaria Vaccine Development, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.}, author = {Shott, Joseph P P. and McGrath, Shannon M M. and Pau, Maria Grazia G. and Custers, Jerome H V H. and Ophorst, Olga and Demoiti\'{e}, Marie-Ange A. and Dubois, Marie-Claude C. and Komisar, Jack and Cobb, Michelle and Kester, Kent E E. and Dubois, Patrice and Cohen, Joe and Goudsmit, Jaap and Heppner, D Gray G. and Stewart, V Ann A.}, citeulike-article-id = {2775368}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.vaccine.2008.03.080}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18455276}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18455276}, day = {16}, doi = {10.1016/j.vaccine.2008.03.080}, issn = {0264-410X}, journal = {Vaccine}, keywords = {antibodies, cs}, month = {April}, posted-at = {2008-05-09 13:08:11}, priority = {2}, title = {Adenovirus 5 and 35 vectors expressing Plasmodium falciparum circumsporozoite surface protein elicit potent antigen-specific cellular IFN-gamma and antibody responses in mice.}, url = {http://dx.doi.org/10.1016/j.vaccine.2008.03.080}, year = {2008} }

TY - JOUR ID - citeulike:2775368 L3 - citeulike-article-id:2775368 N2 - Falciparum malaria vaccine candidates have been developed using recombinant, replication-deficient serotype 5 and 35 adenoviruses (Ad5, Ad35) encoding the Plasmodium falciparum circumsporozoite surface protein (CSP) (Ad5.CS, Ad35.CS) (Crucell Holland BV, Leiden, The Netherlands). To evaluate the immunogenicity of these constructs, BALB/cJ mice were immunized twice with either Ad5.CS, Ad35.CS, empty Ad5-vector (eAd5), empty Ad35 vector (eAd35), or saline. Another group received the CSP-based RTS,S malaria vaccine formulated in the proprietary Adjuvant System AS01B (GlaxoSmithKline Biologicals, Rixensart, Belgium). Here we report that Ad5.CS, Ad35.CS, and RTS,S/AS01B, elicited both cellular and serologic CSP antigen-specific responses in mice. These adenoviral vectors induce strong malaria-specific immunity and warrant further evaluation. JF - Vaccine SN - 0264-410X AD - Division of Malaria Vaccine Development, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA. TI - Adenovirus 5 and 35 vectors expressing Plasmodium falciparum circumsporozoite surface protein elicit potent antigen-specific cellular IFN-gamma and antibody responses in mice. KW - antibodies KW - cs AU - Shott, Joseph P AU - McGrath, Shannon M AU - Pau, Maria Grazia AU - Custers, Jerome H V AU - Ophorst, Olga AU - Demoitié, Marie-Ange AU - Dubois, Marie-Claude AU - Komisar, Jack AU - Cobb, Michelle AU - Kester, Kent E AU - Dubois, Patrice AU - Cohen, Joe AU - Goudsmit, Jaap AU - Heppner, D Gray AU - Stewart, V Ann PY - 2008/04/16/ UR - http://dx.doi.org/10.1016/j.vaccine.2008.03.080 ER -