Anti-mosquito midgut antibodies block development of Plasmodium falciparum and Plasmodium vivax in multiple species of Anopheles mosquitoes and reduce vector fecundity and survivorship. Export

@article{citeulike:2807773, abstract = {The mosquito midgut plays a central role in the sporogonic development of malaria parasites. We have found that polyclonal sera, produced against mosquito midguts, blocked the passage of Plasmodium falciparum ookinetes across the midgut, leading to a significant reduction of infections in mosquitoes. Anti-midgut mAbs were produced that display broad-spectrum activity, blocking parasite development of both P. falciparum and Plasmodium vivax parasites in five different species of mosquitoes. In addition to their parasite transmission-blocking activity, these mAbs also reduced mosquito survivorship and fecundity. These results reveal that mosquito midgut-based antibodies have the potential to reduce malaria transmission in a synergistic manner by lowering both vector competence, through transmission-blocking effects on parasite development, and vector abundance, by decreasing mosquito survivorship and egg laying capacity. Because the intervention can block transmission of different malaria parasite species in various species of mosquitoes, vaccines against such midgut receptors may block malaria transmission worldwide.}, author = {Lal, A. A. and Patterson, P. S. and Sacci, J. B. and Vaughan, J. A. and Paul, C. and Collins, W. E. and Wirtz, R. A. and Azad, A. F.}, citeulike-article-id = {2807773}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.091447398}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11309510}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11309510}, day = {24}, doi = {10.1073/pnas.091447398}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {fecundity, survivorship, transmission-blocking}, month = {April}, number = {9}, pages = {5228--5233}, posted-at = {2008-05-17 15:23:47}, priority = {2}, title = {Anti-mosquito midgut antibodies block development of Plasmodium falciparum and Plasmodium vivax in multiple species of Anopheles mosquitoes and reduce vector fecundity and survivorship.}, url = {http://dx.doi.org/10.1073/pnas.091447398}, volume = {98}, year = {2001} }

TY - JOUR ID - citeulike:2807773 L3 - citeulike-article-id:2807773 N2 - The mosquito midgut plays a central role in the sporogonic development of malaria parasites. We have found that polyclonal sera, produced against mosquito midguts, blocked the passage of Plasmodium falciparum ookinetes across the midgut, leading to a significant reduction of infections in mosquitoes. Anti-midgut mAbs were produced that display broad-spectrum activity, blocking parasite development of both P. falciparum and Plasmodium vivax parasites in five different species of mosquitoes. In addition to their parasite transmission-blocking activity, these mAbs also reduced mosquito survivorship and fecundity. These results reveal that mosquito midgut-based antibodies have the potential to reduce malaria transmission in a synergistic manner by lowering both vector competence, through transmission-blocking effects on parasite development, and vector abundance, by decreasing mosquito survivorship and egg laying capacity. Because the intervention can block transmission of different malaria parasite species in various species of mosquitoes, vaccines against such midgut receptors may block malaria transmission worldwide. IS - 9 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 0027-8424 EP - 5233 TI - Anti-mosquito midgut antibodies block development of Plasmodium falciparum and Plasmodium vivax in multiple species of Anopheles mosquitoes and reduce vector fecundity and survivorship. VL - 98 SP - 5228 KW - fecundity KW - survivorship KW - transmission-blocking AU - Lal, AA AU - Patterson, PS AU - Sacci, JB AU - Vaughan, JA AU - Paul, C AU - Collins, WE AU - Wirtz, RA AU - Azad, AF PY - 2001/04/24/ UR - http://dx.doi.org/10.1073/pnas.091447398 ER -