Micronemal transport of Plasmodium ookinete chitinases to the electron-dense area of the apical complex for extracellular secretion. Export

@article{citeulike:928569, abstract = {Plasmodium ookinetes secrete chitinases to penetrate the acellular, chitin-containing peritrophic matrix of the mosquito midgut en route to invasion of the epithelium. Chitinases are potentially targets that can be used to block malaria transmission. We demonstrate here that chitinases of Plasmodium falciparum and P. gallinaceum are concentrated at the apical end of ookinetes. The chitinase PgCHT1 of P. gallinaceum is present within ookinete micronemes and subsequently becomes localized in the electron-dense area of the apical complex. These observations suggest a pathway by which ookinetes secrete proteins extracellularly.}, address = {World Health Organization Collaborating Center for Tropical Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555-0609, USA.}, author = {Langer, R. C. and Hayward, R. E. and Tsuboi, T. and Tachibana, M. and Torii, M. and Vinetz, J. M.}, citeulike-article-id = {928569}, citeulike-linkout-0 = {http://dx.doi.org/10.1128/IAI.68.11.6461-6465.2000}, citeulike-linkout-1 = {http://iai.asm.org/cgi/content/abstract/68/11/6461}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/11035760}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=11035760}, doi = {10.1128/IAI.68.11.6461-6465.2000}, issn = {0019-9567}, journal = {Infect Immun}, keywords = {cht1, ifa, microneme, secretion}, month = {November}, number = {11}, pages = {6461--6465}, posted-at = {2006-11-04 17:15:53}, priority = {2}, title = {Micronemal transport of Plasmodium ookinete chitinases to the electron-dense area of the apical complex for extracellular secretion.}, url = {http://dx.doi.org/10.1128/IAI.68.11.6461-6465.2000}, volume = {68}, year = {2000} }

TY - JOUR ID - citeulike:928569 L3 - citeulike-article-id:928569 N2 - Plasmodium ookinetes secrete chitinases to penetrate the acellular, chitin-containing peritrophic matrix of the mosquito midgut en route to invasion of the epithelium. Chitinases are potentially targets that can be used to block malaria transmission. We demonstrate here that chitinases of Plasmodium falciparum and P. gallinaceum are concentrated at the apical end of ookinetes. The chitinase PgCHT1 of P. gallinaceum is present within ookinete micronemes and subsequently becomes localized in the electron-dense area of the apical complex. These observations suggest a pathway by which ookinetes secrete proteins extracellularly. IS - 11 JF - Infect Immun SN - 0019-9567 AD - World Health Organization Collaborating Center for Tropical Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555-0609, USA. EP - 6465 TI - Micronemal transport of Plasmodium ookinete chitinases to the electron-dense area of the apical complex for extracellular secretion. VL - 68 SP - 6461 KW - cht1 KW - ifa KW - microneme KW - secretion AU - Langer, RC AU - Hayward, RE AU - Tsuboi, T AU - Tachibana, M AU - Torii, M AU - Vinetz, JM PY - 2000/11// UR - http://dx.doi.org/10.1128/IAI.68.11.6461-6465.2000 ER -