High resolution proteome/peptidome analysis of body fluids by capillary electrophoresis coupled with MS Export

@article{citeulike:940322, abstract = {All organisms contain thousands of proteins and peptides in their body fluids. A deeper insight into the functional relevance of these polypeptides under different physiological and pathophysiological conditions and the discovery of specific peptide biomarkers would greatly enhance both diagnosis and therapy of specific diseases. Proteomic methods can provide means to accomplish this grand medical vision. In this review, we will focus on the potential use of proteome analysis for clinical applications, such as disease diagnosis and assessment of response to therapy. We focus on CE coupled with MS (CE-MS) and review in detail different aspects of CE-MS coupling and the results obtained using CE-MS analysis of clinically relevant samples. We also discuss clinical applications of the technology for the diagnosis of renal diseases, urogenital cancer, and arteriosclerosis as well as monitoring the responses to therapeutic interventions.}, address = {Mosaiques Diagnostics \& Therapeutics AG, Hanover, Germany; University of Alabama at Birmingham, Birmingham, AL, USA}, author = {Schiffer, Eric and Mischak, Harald and Novak, Jan}, citeulike-article-id = {940322}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/pmic.200600230}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/113343951/ABSTRACT}, doi = {10.1002/pmic.200600230}, journal = {PROTEOMICS}, keywords = {ce}, number = {20}, pages = {5615--5627}, posted-at = {2006-11-11 13:55:46}, priority = {2}, title = {High resolution proteome/peptidome analysis of body fluids by capillary electrophoresis coupled with MS}, url = {http://dx.doi.org/10.1002/pmic.200600230}, volume = {6}, year = {2006} }

TY - JOUR ID - citeulike:940322 L3 - citeulike-article-id:940322 N2 - All organisms contain thousands of proteins and peptides in their body fluids. A deeper insight into the functional relevance of these polypeptides under different physiological and pathophysiological conditions and the discovery of specific peptide biomarkers would greatly enhance both diagnosis and therapy of specific diseases. Proteomic methods can provide means to accomplish this grand medical vision. In this review, we will focus on the potential use of proteome analysis for clinical applications, such as disease diagnosis and assessment of response to therapy. We focus on CE coupled with MS (CE-MS) and review in detail different aspects of CE-MS coupling and the results obtained using CE-MS analysis of clinically relevant samples. We also discuss clinical applications of the technology for the diagnosis of renal diseases, urogenital cancer, and arteriosclerosis as well as monitoring the responses to therapeutic interventions. IS - 20 JF - PROTEOMICS AD - Mosaiques Diagnostics & Therapeutics AG, Hanover, Germany; University of Alabama at Birmingham, Birmingham, AL, USA EP - 5627 TI - High resolution proteome/peptidome analysis of body fluids by capillary electrophoresis coupled with MS VL - 6 SP - 5615 KW - ce AU - Schiffer, Eric AU - Mischak, Harald AU - Novak, Jan PY - 2006/// UR - http://dx.doi.org/10.1002/pmic.200600230 ER -