Neuropsychiatric applications of DTI - a review. Export

@article{citeulike:2625875, abstract = {Psychiatric disorders are common throughout the world and are a leading cause of disability. There is a growing appreciation of the importance of connectivity to brain function. Disruption of this connectivity can result in brain dysfunction manifested in impaired cognitive functioning and the development of clinical symptoms. White matter forms the basis of anatomical connectivity. Diffusion tensor imaging (DTI) is a useful tool for examining and quantifying white matter microstructure. Clinical research studies in alcoholism, HIV-1 infection, geriatric depression and schizophrenia using DTI have revealed abnormalities in white matter microstructure. The use of complementary imaging methods may be helpful in further characterizing these abnormalities. Other psychiatric disorders may also have white matter involvement amenable to study with DTI. Advances in acquisition and analysis methods will be necessary to further advance work in this field. The study of animal models and postmortem tissue may be helpful in elucidating the neurobiological underpinnings of abnormalities observed with DTI.}, address = {Department of Psychiatry, University of Minnesota, Minneapolis 55454, USA. kolim@umn.edu}, author = {Lim, K. O. and Helpern, J. A.}, citeulike-article-id = {2625875}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/nbm.789}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12489105}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12489105}, doi = {10.1002/nbm.789}, issn = {0952-3480}, journal = {NMR in biomedicine}, keywords = {anatomical-connectivity, dti, pathophysiology, review}, number = {7-8}, pages = {587--593}, posted-at = {2008-10-16 13:12:09}, priority = {2}, title = {Neuropsychiatric applications of DTI - a review.}, url = {http://dx.doi.org/10.1002/nbm.789}, volume = {15}, year = {2002} }

TY - JOUR ID - citeulike:2625875 L3 - citeulike-article-id:2625875 N2 - Psychiatric disorders are common throughout the world and are a leading cause of disability. There is a growing appreciation of the importance of connectivity to brain function. Disruption of this connectivity can result in brain dysfunction manifested in impaired cognitive functioning and the development of clinical symptoms. White matter forms the basis of anatomical connectivity. Diffusion tensor imaging (DTI) is a useful tool for examining and quantifying white matter microstructure. Clinical research studies in alcoholism, HIV-1 infection, geriatric depression and schizophrenia using DTI have revealed abnormalities in white matter microstructure. The use of complementary imaging methods may be helpful in further characterizing these abnormalities. Other psychiatric disorders may also have white matter involvement amenable to study with DTI. Advances in acquisition and analysis methods will be necessary to further advance work in this field. The study of animal models and postmortem tissue may be helpful in elucidating the neurobiological underpinnings of abnormalities observed with DTI. IS - 7-8 JF - NMR in biomedicine SN - 0952-3480 AD - Department of Psychiatry, University of Minnesota, Minneapolis 55454, USA. kolim@umn.edu EP - 593 TI - Neuropsychiatric applications of DTI - a review. VL - 15 SP - 587 KW - anatomical-connectivity KW - dti KW - pathophysiology KW - review AU - Lim, KO AU - Helpern, JA PY - 2002///c UR - http://dx.doi.org/10.1002/nbm.789 ER -