Transformation of olfactory representations in the Drosophila antennal lobe. Export

@article{citeulike:3085398, abstract = {Molecular genetics has revealed a precise stereotypy in the projection of primary olfactory sensory neurons onto secondary neurons. A major challenge is to understand how this mapping translates into odor responses in these second-order neurons. We investigated this question in Drosophila using whole-cell recordings in vivo. We observe that monomolecular odors generally elicit responses in large ensembles of antennal lobe neurons. Comparison of odor-evoked activity from afferents and postsynaptic neurons in the same glomerulus revealed that second-order neurons display broader tuning and more complex responses than their primary afferents. This indicates a major transformation of odor representations, implicating lateral interactions within the antennal lobe.}, address = {Division of Biology, 139-74, California Institute of Technology, Pasadena, CA 91125, USA.}, author = {Wilson, Rachel I. and Turner, Glenn C. and Laurent, Gilles}, citeulike-article-id = {3085398}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1090782}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/14684826}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=14684826}, day = {16}, doi = {10.1126/science.1090782}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {dal, in-vivo, olfactory, postsynapse}, month = {January}, number = {5656}, pages = {366--370}, posted-at = {2008-12-11 12:56:02}, priority = {2}, title = {Transformation of olfactory representations in the Drosophila antennal lobe.}, url = {http://dx.doi.org/10.1126/science.1090782}, volume = {303}, year = {2004} }

TY - JOUR ID - citeulike:3085398 L3 - citeulike-article-id:3085398 N2 - Molecular genetics has revealed a precise stereotypy in the projection of primary olfactory sensory neurons onto secondary neurons. A major challenge is to understand how this mapping translates into odor responses in these second-order neurons. We investigated this question in Drosophila using whole-cell recordings in vivo. We observe that monomolecular odors generally elicit responses in large ensembles of antennal lobe neurons. Comparison of odor-evoked activity from afferents and postsynaptic neurons in the same glomerulus revealed that second-order neurons display broader tuning and more complex responses than their primary afferents. This indicates a major transformation of odor representations, implicating lateral interactions within the antennal lobe. IS - 5656 JF - Science (New York, N.Y.) SN - 1095-9203 AD - Division of Biology, 139-74, California Institute of Technology, Pasadena, CA 91125, USA. EP - 370 TI - Transformation of olfactory representations in the Drosophila antennal lobe. VL - 303 SP - 366 KW - dal KW - in-vivo KW - olfactory KW - postsynapse AU - Wilson, Rachel AU - Turner, Glenn AU - Laurent, Gilles PY - 2004/01/16/ UR - http://dx.doi.org/10.1126/science.1090782 ER -