Toward a genome-wide systems biology analysis of host-pathogen interactions in group A Streptococcus. Export

@article{citeulike:3563725, abstract = {Genome-wide analysis of microbial pathogens and molecular pathogenesis processes has become an area of considerable activity in the last 5 years. These studies have been made possible by several advances, including completion of the human genome sequence, publication of genome sequences for many human pathogens, development of microarray technology and high-throughput proteomics, and maturation of bioinformatics. Despite these advances, relatively little effort has been expended in the bacterial pathogenesis arena to develop and use integrated research platforms in a systems biology approach to enhance our understanding of disease processes. This review discusses progress made in exploiting an integrated genome-wide research platform to gain new knowledge about how the human bacterial pathogen group A Streptococcus causes disease. Results of these studies have provided many new avenues for basic pathogenesis research and translational research focused on development of an efficacious human vaccine and novel therapeutics. One goal in summarizing this line of study is to bring exciting new findings to the attention of the investigative pathology community. In addition, we hope the review will stimulate investigators to consider using analogous approaches for analysis of the molecular pathogenesis of other microbes.}, author = {Musser, J. M. and DeLeo, F. R.}, citeulike-article-id = {3563725}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/16314461}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=16314461}, issn = {0002-9440}, journal = {The American journal of pathology}, keywords = {bacteria, genomics, host-pathogen, infection, streptococcus}, month = {December}, number = {6}, pages = {1461--1472}, posted-at = {2008-11-18 03:31:59}, priority = {3}, title = {Toward a genome-wide systems biology analysis of host-pathogen interactions in group A Streptococcus.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/16314461}, volume = {167}, year = {2005} }

TY - JOUR ID - citeulike:3563725 L3 - citeulike-article-id:3563725 N2 - Genome-wide analysis of microbial pathogens and molecular pathogenesis processes has become an area of considerable activity in the last 5 years. These studies have been made possible by several advances, including completion of the human genome sequence, publication of genome sequences for many human pathogens, development of microarray technology and high-throughput proteomics, and maturation of bioinformatics. Despite these advances, relatively little effort has been expended in the bacterial pathogenesis arena to develop and use integrated research platforms in a systems biology approach to enhance our understanding of disease processes. This review discusses progress made in exploiting an integrated genome-wide research platform to gain new knowledge about how the human bacterial pathogen group A Streptococcus causes disease. Results of these studies have provided many new avenues for basic pathogenesis research and translational research focused on development of an efficacious human vaccine and novel therapeutics. One goal in summarizing this line of study is to bring exciting new findings to the attention of the investigative pathology community. In addition, we hope the review will stimulate investigators to consider using analogous approaches for analysis of the molecular pathogenesis of other microbes. IS - 6 JF - The American journal of pathology SN - 0002-9440 EP - 1472 TI - Toward a genome-wide systems biology analysis of host-pathogen interactions in group A Streptococcus. VL - 167 SP - 1461 KW - bacteria KW - genomics KW - host-pathogen KW - infection KW - streptococcus AU - Musser, JM AU - DeLeo, FR PY - 2005/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/16314461 ER -