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From Logical Regulatory Graphs to Standard Petri Nets: Dynamical Roles and Functionality of Feedback Circuits Export

Transactions on Computational Systems Biology VII (2006), pp. 56-72.

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Logical modelling and Petri nets constitute two complementary approaches for the dynamical modelling of biological regulatory networks. Leaning on a translation of logical models into standard Petri nets, we propose a formalisation of the notion of circuit functionality in the Petri net framework. This approach is illustrated with the modelling and analysis of a molecular regulatory network involved in the control of Th-lymphocyte differentiation. Keywords: genetic regulatory graphs, Petri nets, feedback circuit, discrete dynamics, qualitative analysis.


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