Evaluation of the vascular architecture of hepatocellular carcinoma by micro flow imaging: pathologic correlation. Export

@article{Yang07, abstract = {OBJECTIVE: The purpose of this study was to evaluate micro flow imaging (MFI) in depicting the vascular architecture of hepatocellular carcinoma (HCC) and the correlation between pathologic differentiation and the intratumoral vascular architecture pattern. METHODS: Micro flow imaging and contrast harmonic imaging (CHI) were performed in 37 patients with HCC. A sulfur hexafluoride-filled microbubble contrast agent was used. The enhancement level and intratumoral vessels were evaluated on CHI. The vascular architecture of each tumor was evaluated on MFI. Pathologic differentiation of the tumors was classified according to the Edmondson grading system. RESULTS: All 37 HCCs showed hyperenhancement in the arterial phase and hypoenhancement in the portal and late phases on CHI. Intratumoral vessels in the arterial phase were visualized in 20 (54.1\%) HCCs. On MFI, the vascular architecture in all lesions was clearly delineated and categorized into 3 patterns: cotton, shrubbery, and deadwood, identified in 12 (32.4\%), 22 (59.5\%), and 3 (8.1\%) of the tumors evaluated, respectively. A chi(2) test showed that pathologic differentiation significantly correlated to the vascular pattern (P = .006). Three (75\%) of 4 Edmondson grade I HCCs showed the cotton pattern; 18 (75.0\%) of 24 Edmondson grade II HCCs showed the shrubbery pattern; and the deadwood pattern was shown only in Edmondson grade III and IV HCCs. CONCLUSIONS: The MFI technique is more effective in depicting the intratumoral vascular architecture. The vascular architecture pattern correlates with pathologic differentiation of HCC.}, address = {Departments of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.}, author = {Yang, H. and Liu, G. J. and Lu, M. D. and Xu, H. X. and Xie, X. Y.}, citeulike-article-id = {1290199}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/17384043}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=17384043}, issn = {0278-4297}, journal = {J Ultrasound Med}, keywords = {contrast, topology, ultrasound, vessel}, month = {April}, number = {4}, pages = {461--467}, posted-at = {2007-05-11 16:56:26}, priority = {2}, title = {Evaluation of the vascular architecture of hepatocellular carcinoma by micro flow imaging: pathologic correlation.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/17384043}, volume = {26}, year = {2007} }

TY - JOUR ID - Yang07 L3 - citeulike-article-id:1290199 N2 - OBJECTIVE: The purpose of this study was to evaluate micro flow imaging (MFI) in depicting the vascular architecture of hepatocellular carcinoma (HCC) and the correlation between pathologic differentiation and the intratumoral vascular architecture pattern. METHODS: Micro flow imaging and contrast harmonic imaging (CHI) were performed in 37 patients with HCC. A sulfur hexafluoride-filled microbubble contrast agent was used. The enhancement level and intratumoral vessels were evaluated on CHI. The vascular architecture of each tumor was evaluated on MFI. Pathologic differentiation of the tumors was classified according to the Edmondson grading system. RESULTS: All 37 HCCs showed hyperenhancement in the arterial phase and hypoenhancement in the portal and late phases on CHI. Intratumoral vessels in the arterial phase were visualized in 20 (54.1%) HCCs. On MFI, the vascular architecture in all lesions was clearly delineated and categorized into 3 patterns: cotton, shrubbery, and deadwood, identified in 12 (32.4%), 22 (59.5%), and 3 (8.1%) of the tumors evaluated, respectively. A chi(2) test showed that pathologic differentiation significantly correlated to the vascular pattern (P = .006). Three (75%) of 4 Edmondson grade I HCCs showed the cotton pattern; 18 (75.0%) of 24 Edmondson grade II HCCs showed the shrubbery pattern; and the deadwood pattern was shown only in Edmondson grade III and IV HCCs. CONCLUSIONS: The MFI technique is more effective in depicting the intratumoral vascular architecture. The vascular architecture pattern correlates with pathologic differentiation of HCC. IS - 4 JF - J Ultrasound Med SN - 0278-4297 AD - Departments of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. EP - 467 TI - Evaluation of the vascular architecture of hepatocellular carcinoma by micro flow imaging: pathologic correlation. VL - 26 SP - 461 KW - contrast KW - topology KW - ultrasound KW - vessel AU - Yang, H AU - Liu, GJ AU - Lu, MD AU - Xu, HX AU - Xie, XY PY - 2007/04// UR - http://view.ncbi.nlm.nih.gov/pubmed/17384043 ER -