The immunopathogenesis of rheumatoid arthritis. Export

@article{citeulike:5064574, abstract = {Rheumatoid arthritis is a chronic inflammatory polyarthritis whose etiology remains uncertain. Recently we have learned that autoimmunity to citrullinated protein antigens has specificity for rheumatoid arthritis and defines a clinically and genetically distinct form of the disease. Multiple genes contribute to disease susceptibility, with the HLA locus accounting for 30\% to 50\% of overall genetic risk. Five risk loci have been identified and validated: HLA-DRB1, PTPN22, STAT4, a region in 6q23, and the TRAF1/C5 locus. Also, there is renewed interest in the contribution of T cells to ongoing inflammation in rheumatoid arthritis. Autoantibodies to citrullinated protein epitopes are specific for rheumatoid arthritis, are associated with a more aggressive disease course, and are pathogenic in an animal model of autoimmune arthritis. There is a strong association between shared-epitope-expressing HLA-DRB1 alleles and the development of rheumatoid arthritis associated with autoimmunity to citrullinated protein antigens.}, author = {Imboden, J. B.}, citeulike-article-id = {5064574}, citeulike-linkout-0 = {http://dx.doi.org/10.1146/annurev.pathol.4.110807.092254}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18954286}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18954286}, doi = {10.1146/annurev.pathol.4.110807.092254}, issn = {1553-4014}, journal = {Annual review of pathology}, keywords = {ra}, pages = {417--434}, posted-at = {2009-07-05 14:35:22}, priority = {5}, title = {The immunopathogenesis of rheumatoid arthritis.}, url = {http://dx.doi.org/10.1146/annurev.pathol.4.110807.092254}, volume = {4}, year = {2009} }

TY - JOUR ID - citeulike:5064574 L3 - citeulike-article-id:5064574 N2 - Rheumatoid arthritis is a chronic inflammatory polyarthritis whose etiology remains uncertain. Recently we have learned that autoimmunity to citrullinated protein antigens has specificity for rheumatoid arthritis and defines a clinically and genetically distinct form of the disease. Multiple genes contribute to disease susceptibility, with the HLA locus accounting for 30% to 50% of overall genetic risk. Five risk loci have been identified and validated: HLA-DRB1, PTPN22, STAT4, a region in 6q23, and the TRAF1/C5 locus. Also, there is renewed interest in the contribution of T cells to ongoing inflammation in rheumatoid arthritis. Autoantibodies to citrullinated protein epitopes are specific for rheumatoid arthritis, are associated with a more aggressive disease course, and are pathogenic in an animal model of autoimmune arthritis. There is a strong association between shared-epitope-expressing HLA-DRB1 alleles and the development of rheumatoid arthritis associated with autoimmunity to citrullinated protein antigens. JF - Annual review of pathology SN - 1553-4014 EP - 434 TI - The immunopathogenesis of rheumatoid arthritis. VL - 4 SP - 417 KW - ra AU - Imboden, JB PY - 2009/// UR - http://dx.doi.org/10.1146/annurev.pathol.4.110807.092254 ER -